Cutaneous Notch Signaling in Health and Disease
Cutaneous Notch Signaling in Health and Disease
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DOI：
10.1101/cshperspect.a017772
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发表时间：
2013-12-01
影响因子：
5.4
通讯作者：
Radtke, Freddy
中科院分区：
文献类型：
--
作者：
Nowell, Craig;Radtke, Freddy
皮肤的发育和维护依赖于调节多种细胞过程的无数信号通路。在皮肤上皮细胞中，Notch 级联在确保增殖和分化适当协调方面发挥着核心作用，这是它在个体发育和稳态过程中赋予的功能。 Notch 信号通路的异常会导致表皮及其附属器的严重异常，并导致功能缺陷，例如屏障功能紊乱。此外，Notch 信号传导受损与特应性和癌症等皮肤疾病有关。与异常皮肤Notch信号传导相关的病理反映了支撑其在该组织中的功能的复杂机制，并且涉及细胞自主和非自主机制。这篇综述总结了我们目前对健康和疾病期间 Notch 信号在皮肤中的作用的了解。
The development and maintenance of the skin are dependent on myriad signaling pathways that regulate a variety of cellular processes. In cutaneous epithelial cells, the Notch cascade plays a central role in ensuring that proliferation and differentiation are coordinated appropriately, a function that it imparts during both ontogeny and homeostasis. Aberrations of the Notch signaling pathway result in severe abnormalities in the epidermis and its appendages and cause functional defects such as perturbed barrier function. In addition, impaired Notch signaling is associated with diseases of the skin such as atopy and cancer. The pathology associated with aberrant cutaneous Notch signaling reflects the complex mechanisms underpinning its function in this tissue and involves both cell-autonomous and nonautonomous mechanisms. This review summarizes our current knowledge of the role of Notch signaling in the skin during health and disease.