Abdominal Obesity Is More Strongly Correlated with Obstructive Sleep Apnea than General Obesity in China: Results from Two Separated Observational and Longitudinal Studies
Abdominal Obesity Is More Strongly Correlated with Obstructive Sleep Apnea than General Obesity in China: Results from Two Separated Observational and Longitudinal Studies
复制标题
在中国，腹部肥胖与阻塞性睡眠呼吸暂停的相关性比一般肥胖的相关性更强：两项独立的观察性和纵向研究的结果
DOI：
10.1007/s11695-019-03870-z
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发表时间：
2019-08-01
期刊：
影响因子：
2.9
通讯作者：
Yin, Shankai
中科院分区：
文献类型：
--
作者：
Zhao, Xiaolong;Xu, Huajun;Yin, Shankai
BackgroundPrevious studies have reported that obesity can result in or worsen obstructive sleep apnea (OSA). However, whether abdominal or general obesity indices or visceral adiposity indicators have a stronger association with OSA remains unclear.MethodsThis cross-sectional study included 4344 patients who underwent polysomnography (PSG) due to suspicion of OSA. We also performed a longitudinal study on 86 patients who underwent bariatric surgery to confirm the relationship between OSA and obesity. Data on overnight PSG parameters, biochemical biomarkers, and multiple anthropometric obesity indices were collected.ResultsIn the cross-sectional study, waist circumference (WC) and body mass index (BMI) were independently associated with the apnea-hypopnea index (AHI) after adjusting for potential confounding factors (additionalR2= 0.232, standardized beta coefficient [Beta] = 0.210; and additionalR2= 0.015, Beta = 0.183, respectively). Logistic regression analysis showed similar results, as did stratified analysis of adult males aged ≤ 55 years. Restricted cubic spline (RCS) analysis revealed a linear dose-response relationship between OSA and obesity. In the longitudinal study, no significant relationship was found between remission of OSA and improvement in WC and BMI (r= 0.252,p= 0.098; andr= 0.132,p= 0.395, respectively), whereas the change in the visceral adiposity indicator (lipid accumulation calculated according to WC and fasting triglycerides) was significantly correlated with ΔAHI (r= 0.322,p= 0.033).ConclusionsAbdominal obesity, rather than general obesity, appears to play a more important role in OSA.
