Neonatal hypoxia in the rat: effects on exocrine pancreatic development.
Neonatal hypoxia in the rat: effects on exocrine pancreatic development.
复制标题
大鼠新生儿缺氧：对外分泌胰腺发育的影响。
DOI：
10.1097/00005176-200205000-00013
复制
发表时间：
2002
影响因子：
2.9
通讯作者：
Raff,Hershel
中科院分区：
文献类型：
--
作者：
Lee,PingC;Struve,Mark;Lewis,SuzanM;Raff,Hershel
背景糖皮质激素对哺乳期胰腺发育有重要影响。增加循环糖皮质激素在暴露于缺氧可能会改变正常模式的胰腺酶development.MethodsRats暴露于缺氧从出生到7天（哺乳）或从28至35天的年龄（断奶在第21天）。ResultsHypoxia在新生大鼠（0-7天）导致胰腺重量下降，胰蛋白酶，脂肪酶，淀粉酶活性与常氧对照组相比。相反，暴露于缺氧的大鼠从28日龄至35日龄的脂肪酶活性下降，但在其他胰腺参数没有变化。缺氧两周后（0-7天），幼崽恢复到常氧状态，其体重仍小于年龄匹配的先前常氧对照组。与对照组相比，缺氧恢复组胰腺酶活性降低。低氧大鼠恢复常氧后3周，观察到酶活性的恢复。常氧幼鼠给予地塞米松以模拟7日奥尔兹时低氧环境下的高糖皮质激素状态。地塞米松管理导致体重下降，但增加胰腺重量和酶活性与常氧，年龄匹配的controls.ConclusionsHypoxia新生大鼠延迟胰腺外分泌酶的成熟。其机制与血清糖皮质激素水平升高无关。
BackgroundGlucocorticoids profoundly affect pancreatic development during the suckling period. Increases in circulating glucocorticoids during exposure to hypoxia may alter the normal pattern of pancreatic enzyme development.MethodsRats were exposed to hypoxia from birth to 7 days (suckling) or from 28 to 35 days of age (weaned at day 21).ResultsHypoxia in neonatal rats (0–7 days) led to decreased pancreatic weight, and trypsin, lipase, and amylase activity compared with normoxic controls. In contrast, rats exposed to hypoxia from 28 to 35 days of age had decreased lipase activity but no change in other pancreatic parameters. Two weeks after hypoxia (0–7 days) pups were returned to normoxia, and their body weights remained smaller than the age-matched, previously normoxic controls. Pancreatic enzyme activities were decreased in the group recovering from hypoxia compared with controls. Recovery of enzyme activities was observed 3 weeks after hypoxic rats were returned to normoxia. Normoxic pups were given dexamethasone to simulate the hyperglucocorticoid state in hypoxia at 7-day olds. Dexamethasone administration led to decreased body weight, but increased pancreatic weight and enzyme activity compared with normoxic, age-matched controls.ConclusionsHypoxia in newborn rats delays the maturation of pancreatic exocrine enzymes. The mechanism is not related to increased serum glucocorticoids.