Recent Progress in Opioid Research from an Electrophysiological Perspective.
Recent Progress in Opioid Research from an Electrophysiological Perspective.
复制标题
DOI：
10.1124/mol.119.119040
复制
发表时间：
2020-10
影响因子：
3.6
通讯作者：
Williams JT
中科院分区：
文献类型：
--
作者：
Birdsong WT;Williams JT
电生理学方法提供了强大的工具来进一步了解不同的阿片类药物如何通过阿片受体影响信号传递；阿片受体如何调节参与疼痛、呼吸、成瘾和摄食等过程的电路；以及受体信号和电路如何因生理挑战而改变，如损伤、应激和慢性阿片类药物治疗。利用基因操作改变或移除具有解剖和细胞类型特异性的μ-阿片受体(MORs)，以及通过光或化学遗传学方法激活或抑制特定电路的能力，正在与电生理学、药理学和系统水平的生理学实验相结合，以扩大我们对阿片和阿片受体信号的有益和不适应作用的理解。研究内源性阿片肽信号和释放以及这些系统在慢性阿片类药物使用、疼痛和应激反应中的动力学的新方法将为我们理解复杂的阿片类药物大脑回路调节增加另一个层次。这一认识可能导致药物开发或治疗方案的新靶点或方法，这些药物或治疗方案可能会影响操纵参与阿片介导的生理和行为的回路活动的急性和长期效果。这篇综述将讨论我们对磷酸化在调节MOR信号中的作用以及我们对调节呼吸控制等生理行为的通路和信号通路的理解的最新进展，并讨论电生理工具与新技术相结合如何已经并将继续推动阿片类药物研究领域的发展。本文综述了近年来对μ-阿片受体(MOR)功能和调控的研究进展，以及电生理方法与新技术相结合在推动阿片类药物研究领域的作用。这包括在受体水平上对MOR的调节，慢性阿片类药物治疗诱导的适应，MOR对特定大脑回路的调节作用部位，以及内源性阿片系统通过调节这些大脑回路在驱动生理和行为中的作用。
Electrophysiological approaches provide powerful tools to further our understanding of how different opioids affect signaling through opioid receptors; how opioid receptors modulate circuitry involved in processes such as pain, respiration, addiction, and feeding; and how receptor signaling and circuits are altered by physiologic challenges, such as injury, stress, and chronic opioid treatment. The use of genetic manipulations to alter or remove μ-opioid receptors (MORs) with anatomic and cell type specificity and the ability to activate or inhibit specific circuits through opto- or chemogenetic approaches are being used in combination with electrophysiological, pharmacological, and systems-level physiology experiments to expand our understanding of the beneficial and maladaptive roles of opioids and opioid receptor signaling. New approaches for studying endogenous opioid peptide signaling and release and the dynamics of these systems in response to chronic opioid use, pain, and stress will add another layer to our understanding of the intricacies of opioid modulation of brain circuits. This understanding may lead to new targets or approaches for drug development or treatment regimens that may affect both acute and long-term effects of manipulating the activity of circuits involved in opioid-mediated physiology and behaviors. This review will discuss recent advancements in our understanding of the role of phosphorylation in regulating MOR signaling, as well as our understanding of circuits and signaling pathways mediating physiologic behaviors such as respiratory control, and discuss how electrophysiological tools combined with new technologies have and will continue to advance the field of opioid research. This review discusses recent advancements in our understanding of μ-opioid receptor (MOR) function and regulation and the role of electrophysiological approaches combined with new technologies in pushing the field of opioid research forward. This covers regulation of MOR at the receptor level, adaptations induced by chronic opioid treatment, sites of action of MOR modulation of specific brain circuits, and the role of the endogenous opioid system in driving physiology and behavior through modulation of these brain circuits.
登录
查看更多内容
影响因子：
16.2
作者：
Banghart MR;Neufeld SQ;Wong NC;Sabatini BL
通讯作者：
Sabatini BL
影响因子：
5.3
作者：
Blomeley, Craig P.;Bracci, Enrico
通讯作者：
Bracci, Enrico
影响因子：
7.3
作者：
Connor, M.;Bagley, E. E.;Christie, M. J.
通讯作者：
Christie, M. J.
影响因子：
7.3
作者：
Arttamangkul, Seksiri;Birdsong, William;Williams, John T.
通讯作者：
Williams, John T.
影响因子：
3.1
作者：
Erbs E;Faget L;Scherrer G;Matifas A;Filliol D;Vonesch JL;Koch M;Kessler P;Hentsch D;Birling MC;Koutsourakis M;Vasseur L;Veinante P;Kieffer BL;Massotte D
通讯作者：
Massotte D