Acute predator stress impairs the consolidation and retrieval of hippocampus-dependent memory in male and female rats
Acute predator stress impairs the consolidation and retrieval of hippocampus-dependent memory in male and female rats
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DOI：
10.1101/lm.721108
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发表时间：
2008-04-01
影响因子：
2
通讯作者：
Diamond, David M.
中科院分区：
文献类型：
--
作者：
Park, Collin R.;Zoladz, Phillip R.;Diamond, David M.
我们研究了急性捕食者应激经历对成年雄性和雌性SD大鼠空间学习和记忆的影响。所有大鼠都接受了训练，以学习在径向臂水迷宫(RAWM)中隐藏的逃生平台的位置，这是一种依赖海马体的空间记忆任务。在对照(非应激)条件下，雌性大鼠在多天训练中测试的空间记忆表现的准确性和一致性优于雄性大鼠。在应激状态下，大鼠在学习前或学习后即刻或在24小时记忆测试前立即暴露于猫30min。捕食者的压力显著增加了雄性和雌性的皮质酮水平，雌性比雄性表现出更大的基线和压力诱发的反应。尽管皮质酮水平的总体大小存在性别差异，但基础皮质酮水平和压力诱发的皮质酮水平与记忆表现之间存在显著的性别无关相关性。最重要的是，捕食者的压力损害了雄性和雌性大鼠的短期记忆，以及参与记忆巩固和恢复的过程。总体而言，我们发现，强烈的、与行为学相关的应激源在雄性和雌性大鼠中产生的记忆损害基本相同，并且与性别无关的皮质酮-记忆相关性。这些发现可能会提供对创伤应激如何影响男性和女性大脑和记忆的共性的见解。
We have studied the effects of an acute predator stress experience on spatial learning and memory in adult male and female Sprague-Dawley rats. All rats were trained to learn the location of a hidden escape platform in the radial-arm water maze (RAWM), a hippocampus-dependent spatial memory task. In the control (non-stress) condition, female rats were superior to the males in the accuracy and consistency of their spatial memory performance tested over multiple days of training. In the stress condition, rats were exposed to the cat for 30 min immediately before or after learning, or before the 24-h memory test. Predator stress dramatically increased corticosterone levels in males and females, with females exhibiting greater baseline and stress-evoked responses than males. Despite these sex differences in the overall magnitudes of corticosterone levels, there were significant sex-independent correlations involving basal and stress-evoked corticosterone levels, and memory performance. Most importantly, predator stress impaired short-term memory, as well as processes involved in memory consolidation and retrieval, in male and female rats. Overall, we have found that an intense, ethologically relevant stressor produced a largely equivalent impairment of memory in male and female rats, and sex-independent corticosterone-memory correlations. These findings may provide insight into commonalities in how traumatic stress affects the brain and memory in men and women.