RELEASE OF VASOACTIVE INTESTINAL POLYPEPTIDE FROM THE CAT SMALL-INTESTINE EXPOSED TO CHOLERA-TOXIN
RELEASE OF VASOACTIVE INTESTINAL POLYPEPTIDE FROM THE CAT SMALL-INTESTINE EXPOSED TO CHOLERA-TOXIN
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DOI：
10.1136/gut.22.11.958
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发表时间：
1981-01-01
期刊：
影响因子：
24.5
通讯作者：
LUNDGREN, O
中科院分区：
文献类型：
--
作者：
CASSUTO, J;FAHRENKRUG, J;LUNDGREN, O
在四个小时的观察期内，暴露在霍乱毒素下的猫小肠会释放越来越多的血管活性肠多肽(VIP)。由于已知VIP几乎只位于肠道神经中，目前的发现强烈表明霍乱毒素激活了肠道神经系统。这项研究和在该实验室进行的其他研究的结果导致了这样的假设，即霍乱分泌物至少在一定程度上是肠道内神经反射激活的次要因素。
During a four hour observation period vasoactive intestinal polypeptide (VIP) is released in increasing amounts from the feline small intestine exposed to cholera toxin. As VIP is known to be located almost exclusively in the intestinal nerves, the present findings strongly suggest that cholera toxin activates the enteric nervous system. The findings of this and other studies performed in this laboratory lead to the proposal that the choleraic secretion is, at least in part, secondary to the activation of intramural nervous reflexes in the gut.