SPECIFIC NEUROANATOMICAL CHANGES IN CHEMOSENSORY MUTANTS OF NEMATODE CAENORHABDITIS-ELEGANS
SPECIFIC NEUROANATOMICAL CHANGES IN CHEMOSENSORY MUTANTS OF NEMATODE CAENORHABDITIS-ELEGANS
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DOI：
10.1002/cne.901720306
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发表时间：
1977-01-01
影响因子：
2.5
通讯作者：
HODGKIN, JA
中科院分区：
文献类型：
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作者：
LEWIS, JA;HODGKIN, JA
在线虫的19个趋化突变体中，8个在头尖神经元的感觉末梢存在形态缺陷。这些突变体是在蠕虫远离引诱剂时获得的，或者在雄性效力突变体或表现出不稳定行为的突变体中发现的。这19个突变体属于至少12个互补基团。突变体E1034和E1035是che-1的等位基因，在两侧神经元和内唇2型神经元的感觉末梢上表现出形态改变，这两种神经元都是未来的化学感觉神经元。两个突变体都含有与化学感觉突变相关的非互补的不育突变。E1066显示与感觉神经元相关的鞘细胞和两侧神经元的束状模式均出现异常。E1126仅在唇内2型神经元的感觉末梢出现结构异常，支持这些神经元的化学感觉作用。E1033 （che-2）和E1124 （che-3）导致头部除1种纤毛感觉神经元外的所有纤毛结构缺损。E1062在头部结构和雄性交配器官结构上存在严重缺陷，这表明这两种具有丰富感觉结构的线虫在胚胎发生过程中具有相同的基因功能。提出了在简单生物体中对一小组神经的发育进行遗传解剖的可能性。
Of 19 chemotactic mutants of the nematode C. elegans 8 had morphological defects in the sensory endings of neurons at the tip of the head. The mutants were obtained as worms swimming away from attractant or found among male potency mutants or mutants exhibiting erratic behavior. The 19 mutants fall into at least 12 complementation groups. Mutants E1034 and E1035, alleles of che-1, showed morphological alterations in the sensory endings of amphidial neurons and inner labial type 2 neurons, both prospective chemosensory neurons. Both mutants contained non-complementing ts sterile mutations linked to the chemosensory mutation. E1066 showed abnormalities in all the sheath cells associated with the sensory neurons and in the bundling pattern of the amphidial neurons. E1126 was structurally abnormal only in the sensory endings of inner labial type 2 neurons, supporting a chemosensory role for these neurons. E1033 (che-2) and E1124 (che-3) caused defects in the ciliary structure of all but 1 type of ciliated sensory neuron in the head. E1062 was grossly defective in head structure and the structure of the male copulatory organ, suggesting these opposite ends of the nematode rich in sensory structures share gene functions in embryogenesis. Possibilities for genetic dissection of the development of a small set of nerves in a simple organism are suggested.