Determination of the MRI contrast agent Gd-DTPA by SEC-ICP-MS
Determination of the MRI contrast agent Gd-DTPA by SEC-ICP-MS
复制标题
DOI：
10.1007/s00216-004-2700-4
复制
发表时间：
2004-08-01
影响因子：
4.3
通讯作者：
Bettmer, J
中科院分区：
文献类型：
--
作者：
Loreti, V;Bettmer, J
本文报道了Gd~(3+)和常用的对比剂Gd-DTPA(DTPA：二乙三胺五乙酸)的同时测定方法。所提出的方法结合了尺寸排除色谱(SEC)和电感耦合等离子体质谱(ICPMS)进行元素选择性检测，以确定是否存在高分子Gd络合物。将该方法应用于静脉注射Gd-DTPA患者的尿样分析。结果表明，所有样品均未观察到Gd-DTPA的转化或吸附，甚至未检测到游离Gd3+。监测尿液排泄行为，证明Gd-DTPA在一天内几乎完全(~gt；99%)通过排尿排出。头发中可以检测到痕量的Gd-DTPA，但用四甲基氢氧化铵(TMAH)萃取会导致Gd-DTPA的降解。
The simultaneous determination of Gd3+ and Gd-DTPA (DTPA: diethylenetriamino-pentaacetic acid), often used as contrast agent, is described. The proposed approach combines size-exclusion chromatography (SEC) and inductively coupled plasma-mass spectrometry (ICP-MS) for element-selective detection in order to determine also high-molecular Gd-complexes if present. This method was applied to the analysis of urine samples of a patient to whom Gd-DTPA was intravenously administered. The results showed that no conversion or adsorption of Gd-DTPA could be observed in any sample, even free Gd3+ could not be detected. Urine excretion behaviour was monitored and it was proved that Gd-DTPA was almost completely (> 99%) excreted by urination within one day. Traces of Gd-DTPA could be measured in hair samples, but extraction with tetramethylammonium hydroxide (TMAH) resulted in degradation of Gd-DTPA.