Immunodeficiency in female sexual partners of men with the acquired immunodeficiency syndrome.
Immunodeficiency in female sexual partners of men with the acquired immunodeficiency syndrome.
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患有获得性免疫缺陷综合症的男性女性性伴侣的免疫缺陷。
DOI：
10.1056/nejm198305193082001
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Steigbigel,NH
中科院分区：
文献类型：
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作者：
Harris,C;Small,CB;Klein,RS;Friedland,GH;Moll,B;Emeson,EE;Spigland,I;Steigbigel,NH
由于目前在以前健康的成年人中爆发的获得性免疫缺陷综合征（AIDS）可能是由可传播的生物制剂引起的，并且因为它可能是由免疫异常引起的，有或没有前驱疾病，我们研究了患有该综合征的男性患者的7名女性性伴侣。男性患者均为药物滥用者。7名女性中有1名被发现患有全面的综合征，第二名患有与艾滋病前驱症状一致的疾病（全身性淋巴结病，淋巴细胞减少症，辅助性T细胞与抑制性T细胞的比例降低），另外4名患有全身性淋巴结病或淋巴细胞减少症，伴有或不伴有辅助性T细胞与抑制性T细胞的比例降低。只有一个女人没有异常。这些发现表明，艾滋病可能在异性恋男女之间传播。（N Engl J Med 1983; 308：1181-4.）
Because the current outbreak of acquired immunodeficiency syndrome (AIDS) among previously healthy adults may be caused by a transmissible biologic agent, and because it may be preceded by immunologic abnormalities with or without a prodromal illness, we studied seven female sexual partners of male patients with the syndrome. The male patients were all drug abusers. One of the seven women was found to have the full-blown syndrome, a second had an illness consistent with the prodrome of AIDS (generalized lymphadenopathy, lymphopenia, and a decreased ratio of helper to suppressor T cells), and four others had generalized lymphadenopathy or lymphopenia, with or without a decreased ratio of helper to suppressor T cells. Only one woman had no abnormalities. These findings suggest that AIDS may be transmitted between hetero-sexual men and women. (N Engl J Med 1983; 308:1181–4.)