Human phase response curve to a 1 h pulse of bright white light
Human phase response curve to a 1 h pulse of bright white light
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DOI：
10.1113/jphysiol.2012.227892
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发表时间：
2012-07-01
影响因子：
5.5
通讯作者：
Lockley, Steven W.
中科院分区：
文献类型：
--
作者：
St Hilaire, Melissa A.;Gooley, Joshua J.;Lockley, Steven W.
关键点人类昼夜节律起搏器产生近24小时的节奏，设定许多生理，代谢和行为的身体节奏的时间，并同步到环境时间主要是由24小时光暗周期。起搏器对光的重置响应的幅度和方向取决于一天中暴露的时间，并且在一天中响应的变化总结在相位响应曲线（PRC）中。先前的PRC表明，6.7小时的明亮白色光暴露最大限度地改变了超过3小时的昼夜节律起搏器。我们发现，一个PRC的1小时明亮的白色光脉冲最大限度地改变了昼夜节律起搏器的相似2小时，尽管只代表类似的曝光时间的15%。本研究表明，昼夜节律起搏器是敏感的短持续时间的光脉冲与光的持续时间和重置量之间的非线性关系。摘要人体昼夜节律起搏器对光的相位重置响应依赖于曝光时间，并由相位响应曲线（PRC）描述。本研究旨在构建暴露于明亮白色光（类似于8000勒克斯）1小时的PRC，并将该PRC与
Key points The human circadian pacemaker generates near-24-h rhythms that set the timing of many physiological, metabolic and behavioural body rhythms, and is synchronized to environmental time primarily by the 24 h lightdark cycle. The magnitude and direction of the resetting response of the pacemaker to light depends on the time of day of exposure, and the change in responses over the day is summarized in a phase response curve (PRC). A previous PRC showed that a 6.7 h bright white light exposure maximally shifted the circadian pacemaker by over 3 h. We show that a PRC to a 1 h bright white light pulse maximally shifted the circadian pacemaker by similar to 2 h, despite representing only similar to 15% of the exposure duration. This study demonstrates that the circadian pacemaker is sensitive to short-duration light pulses with a non-linear relationship between light duration and the amount of resetting. Abstract The phase resetting response of the human circadian pacemaker to light depends on the timing of exposure and is described by a phase response curve (PRC). The current study aimed to construct a PRC for a 1 h exposure to bright white light (similar to 8000 lux) and to compare this PRC to a