Refining psychiatric genetics: from 'mouse psychiatry' to understanding complex human disorders.
Refining psychiatric genetics: from 'mouse psychiatry' to understanding complex human disorders.
复制标题
完善精神遗传学：从“小鼠精神病学”到理解复杂的人类疾病。
DOI：
10.1097/fbp.0b013e32830dc09b
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发表时间：
2008
影响因子：
1.6
通讯作者：
Kalueff,AllanV
中科院分区：
文献类型：
--
作者：
Laporte,JustinL;Ren-Patterson,ReneeF;Murphy,DennisL;Kalueff,AllanV
对于精神遗传学家来说，研究精神疾病的发病机制是一项复杂而严格的任务，因为这些疾病通常涉及遗传、行为、人格和环境因素的组合。为了促进这一领域的进一步进展，除了目前接受的办法之外，还需要一套新的概念工具。考虑到跨物种性状遗传学和疾病领域之间的相互作用，以及潜在症状的全谱及其在致病连续体中的位置沿着的概念，对于满足这些需求特别重要。在这里，我们概述了最近的概念和方法，可以帮助完善该领域，并使更精确的解剖遗传机制有助于精神疾病。
Investigating the pathogenesis of psychiatric disorders is a complicated and rigorous task for psychiatric geneticists, as the disorders often involve combinations of genetic, behavioral, personality, and environmental factors. To nurture further progress in this field, a new set of conceptual tools is needed in addition to the currently accepted approaches. Concepts that consider cross-species trait genetics and the interplay between the domains of disorders, as well as the full spectrum of potential symptoms and their place along the pathogenetic continuum, are particularly important to address these needs. Here, we outline recent concepts and approaches that can help refine the field and enable more precise dissection of the genetic mechanisms contributing to psychiatric disorders.