The incidence rate of post-stroke epilepsy: A 5-year follow-up study in Taiwan
The incidence rate of post-stroke epilepsy: A 5-year follow-up study in Taiwan
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DOI：
10.1016/j.eplepsyres.2012.06.003
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发表时间：
2012-12-01
影响因子：
2.2
通讯作者：
Lai, Chien-Hsu
中科院分区：
文献类型：
--
作者：
Chen, Ta-Cheng;Chen, Yen-Yu;Lai, Chien-Hsu
目的：不同亚型卒中后癫痫的影响尚不清楚。本研究的目的是评估中风后癫痫的风险与不同的中风subtype.Methods：共4126中风患者和24,756年龄和性别匹配的控制，从纵向健康保险数据库2005年，一个主要的数据集的国家健康保险研究数据库，从2000年至2003年检索。然后，所有人都被单独跟踪到他们的最后一次医疗就诊，从他们首次中风事件后30天起长达5年，以确定那些发展为癫痫的人。在4126例卒中患者中，72.2%有缺血性卒中，14.7%有脑内出血（ICH），2.3%有蛛网膜下腔出血（SAH），2.0%有其他和未指明的颅内出血（OIH），包括硬膜下出血和硬膜外出血，8.9%有多种卒中亚型。与对照组相比，卒中患者发生癫痫的校正风险比为11.5（95% CI 8.2-16.2）。2.6%的卒中患者在5年随访期间发生癫痫。脑卒中后癫痫发生率以多亚型患者最高（7.7%），其次为ICH（4.3%）、SAH（4.2%）、OIH（2.5%）和缺血性脑卒中（1.6%）。出血性卒中患者发生卒中后癫痫的风险高于缺血性卒中患者。(C)2012爱思唯尔有限公司版权所有。
Purpose: The impact of epilepsy following different subtypes of stroke is unclear. The aim of this study was to evaluate the risk of post-stroke epilepsy with different stroke subtypes.Methods: A total of 4126 stroke patients and 24,756 age- and sex-matched controls were retrieved from the Longitudinal Health Insurance Database 2005, a major dataset of the National Health Insurance Research Database, from 2000 to 2003. All were then individually tracked to their last medical visit up to five years from 30 days after their first-ever stroke incident to identify those who developed epilepsy.Results: Among the 4126 stroke patients, 72.2% had ischemic stroke, 14.7% had intracerebral hemorrhage (ICH), 2.3% had subarachnoid hemorrhage (SAH), 2.0% had other and unspecified intracranial hemorrhage (OIH), including subdural hemorrhage and epidural hemorrhage, and 8.9% had multiple stroke subtypes. The adjusted hazard ratio for the development of epilepsy was 11.5 (95% CI 8.2-16.2) for the patients with stroke compared to the controls. 2.6% of the patients with stroke developed epilepsy during the 5-year follow-up period. The rate of post-stroke epilepsy was highest in patients with multiple subtypes (7.7%), followed by ICH (4.3%), SAH (4.2%), OIH (2.5%) and ischemic stroke (1.6%).Conclusion: Stroke patients had a significantly higher risk of developing epilepsy than the controls. The risk of post-stroke epilepsy was higher in patients with hemorrhagic stroke than ischemic stroke. (C) 2012 Elsevier B.V. All rights reserved.