Aortic Aneurysms and Dissections Series
Aortic Aneurysms and Dissections Series
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DOI：
10.1161/atvbaha.120.313991
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发表时间：
2020-03-01
影响因子：
8.7
通讯作者：
Lu, Hong S.
中科院分区：
文献类型：
--
作者：
Shen, Ying H.;LeMaire, Scott A.;Lu, Hong S.
主动脉壁由高度动态的细胞群和细胞外基质组成。为了响应生物力学环境的变化，主动脉细胞和细胞外基质调节其结构和功能，以增加主动脉壁强度并满足血流动力学需求。主动脉成分的结构和功能完整性受损会导致主动脉变性、生物力学故障以及主动脉瘤和夹层（AAD）的发展。更好地了解 AAD 的分子发病机制将有助于开发治疗这些疾病的有效药物。在这里，我们总结了 ATVB 上发表的有关 AAD 的最新研究结果。本期我们重点关注AAD中主动脉细胞和细胞外基质的动态变化；下一期，我们将重点关注信号通路在AAD中的作用。
The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In response to changes in the biomechanical environment, aortic cells and extracellular matrix modulate their structure and functions to increase aortic wall strength and meet the hemodynamic demand. Compromise in the structural and functional integrity of aortic components leads to aortic degeneration, biomechanical failure, and the development of aortic aneurysms and dissections (AAD). A better understanding of the molecular pathogenesis of AAD will facilitate the development of effective medications to treat these conditions. Here, we summarize recent findings on AAD published in ATVB. In this issue, we focus on the dynamics of aortic cells and extracellular matrix in AAD; in the next issue, we will focus on the role of signaling pathways in AAD.