Contrast sensitivity function and ocular higher-order aberrations following overnight orthokeratology
Contrast sensitivity function and ocular higher-order aberrations following overnight orthokeratology
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DOI：
10.1167/iovs.06-0914
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发表时间：
2007-02-01
影响因子：
4.4
通讯作者：
Oshika, Tetsuro
中科院分区：
文献类型：
--
作者：
Hiraoka, Takahiro;Okamoto, Chikako;Oshika, Tetsuro
目的.目的探讨角膜塑形术治疗近视患者对比敏感度、高阶像差和近视矫正之间的关系。对23例46眼角膜塑形术患者进行了前瞻性研究。入选标准为等效球镜屈光度在-1.00至-4.00屈光度（D）之间，屈光散光达1.00 D，最佳矫正视力为20/20或更好。术前和术后3个月分别测定眼高阶像差和对比敏感度。我们用CSV-1000图表（Vector Vision Co.，Greenville，OH）。根据对比敏感度数据计算对数对比敏感度函数下的面积（AULCSF）。角膜塑形术显著改善logMAR裸眼视力（P < 0.0001;配对t检验），但显著增加眼高阶像差（P < 0.0001）和对比敏感度功能降低，包括AULCSF（P < 0.0001）、低对比度视力（P = 0.0025）和字母对比敏感度（P < 0.0001; Wilcoxon符号秩检验）。角膜塑形术引起的AULCSF、低对比度视力和字母对比敏感度的变化与三阶变化显著相关，四阶回归分析（Pearson r =-0.430，P = 0.0026; r = 0.423，P = 0.0031;和斯皮尔曼r（s）=-0.351，P = 0.0186），（r =-0.418，P = 0.0035; r = 0.425，P = 0.0029; r（s）=-0.566，P = 0.0001），总高阶（r =-0.460，P = 0.0011; r = 0.471，P = 0.0008; r（s）=-0.434，P = 0.0036）。对比敏感度和高阶像差的变化与近视矫正量显著相关（P < 0.01）。角膜塑形术显著增加了眼高阶像差，并损害了对比敏感度功能，这取决于近视矫正的量。
PURPOSE. To evaluate relationships among contrast sensitivity function, ocular higher-order aberration, and myopic correction in eyes undergoing overnight orthokeratology for myopia.METHODS. A prospective study was conducted in 46 eyes of 23 patients undergoing orthokeratology. Inclusion criteria were spherical equivalent refraction between -1.00 and -4.00 diopters ( D), refractive astigmatism up to 1.00 D, and best-corrected visual acuity of 20/20 or better. Ocular higher-order aberrations and contrast sensitivity function were determined before and 3 months after initiation of the procedure. We measured three indices of contrast sensitivity function: contrast sensitivity, low-contrast visual acuity, and letter contrast sensitivity with the CSV-1000 charts ( Vector Vision Co., Greenville, OH). Area under the log contrast sensitivity function ( AULCSF) was calculated from the contrast sensitivity data.RESULTS. Orthokeratology significantly improved logMAR uncorrected visual acuity ( P < 0.0001; paired t-test) but significantly increased ocular higher-order aberrations ( P < 0.0001) and decreased contrast sensitivity function, including AULCSF ( P < 0.0001), low-contrast visual acuity ( P = 0.0025), and letter contrast sensitivity ( P < 0.0001; Wilcoxon signed-rank test). The induced changes in AULCSF, low-contrast visual acuity, and letter contrast sensitivity by orthokeratology showed significant correlation with changes in third-order ( Pearson r = -0.430, P = 0.0026; r = 0.423, P = 0.0031; and Spearman r(s) = -0.351, P = 0.0186, respectively), fourth-order ( r = -0.418, P = 0.0035; r = 0.425, P = 0.0029; and r(s) = -0.566, P = 0.0001, respectively), and total higher-order ( r = -0.460, P = 0.0011; r = 0.471, P = 0.0008; and r(s) = -0.434, P = 0.0036, respectively) aberrations. The induced changes in contrast sensitivity function and higher-order aberrations significantly correlated with the amount of myopic correction ( P < 0.01).CONCLUSIONS. Orthokeratology significantly increases ocular higher-order aberrations and compromises contrast sensitivity function, depending on the amount of myopic correction.