Effects of early undernutrition and subsequent refeeding on alkaline ribonuclease activity of rat cerebrum and liver.
Effects of early undernutrition and subsequent refeeding on alkaline ribonuclease activity of rat cerebrum and liver.
复制标题
早期营养不良和随后的重新喂养对大鼠大脑和肝脏碱性核糖核酸酶活性的影响。
DOI：
10.1093/jn/105.9.1104
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
M. Winick
中科院分区：
文献类型：
--
作者：
P. Rosso;M. Winick
本实验研究了14日龄和21日龄大鼠营养不良及随后的康复训练对大脑和肝脏游离和总碱性核糖核酸酶活性的影响。在14和21日龄的两个器官中，游离核糖核酸酶活性较高。然而，在第21天，仅肝脏中的差异具有统计学显著性。总RNA酶活性没有改变营养不足的大脑和减少肝脏。营养康复恢复肝脏游离和总RNA酶活性至对照水平，但对大脑无明显影响。游离核糖核酸酶的升高似乎是继发于抑制蛋白浓度的降低，而不是核糖核酸酶的从头合成。
The effect of undernutrition and subsequent rehabilitation on free and total alkaline ribonuclease activity (RNase) of cerebrum and liver was studied in 14- and 21-day-old rats. Free RNase activity was higher in both organs at 14 and 21 days of age. However, at day 21 the difference was statistically significant only in liver. Total RNase activity was not changed by undernutrition in cerebrum and was reduced in liver. Nutritional rehabilitation returned both free and total RNase activities to control levels in liver but had no apparent effect on cerebrum. The elevation of free RNase seems to be secondary to a reduced concentration of inhibitor protein and not to de novo synthesis of RNase.