Local infectious disease experience influences vaccine refusal rates: a natural experiment.
Local infectious disease experience influences vaccine refusal rates: a natural experiment.
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DOI：
10.1098/rspb.2022.1986
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发表时间：
2023-02-08
影响因子：
4.7
通讯作者：
Mancy, Rebecca
中科院分区：
文献类型：
--
作者：
Angelopoulos, Konstantinos;Stewart, Gillian;Mancy, Rebecca
近几个世纪以来，疫苗接种对传染病流行率的下降至关重要。尽管如此，近年来拒绝接种疫苗的情况有所增加，与降低疾病流行率相关的自满情绪突出表明，这是一个重要因素。我们利用20世纪初在格拉斯哥进行的一项自然实验来调查先前的当地传染病经验是否对疫苗接种决策重要。我们的研究基于天花监测数据和父母拒绝为婴儿接种疫苗的管理记录。我们分析了格拉斯哥行政单位在1900-1904年期间两次天花流行期间天花病例和死亡人数的变化，以及1907年苏格兰在长期强制接种后拒绝接种天花疫苗。我们发现，流行期间较低的局部疾病发病率和死亡率与随后较高的疫苗拒接率相关。这一发现表明，在传染病风险较高的时期，自满影响了疫苗接种决定，这是对当地先前相关疾病经验的回应，而不仅仅是在近几十年传染病风险普遍较低的背景下出现的。这些结果表明，疫苗交付策略可能受益于有关发病率局部差异的信息。
Vaccination has been critical to the decline in infectious disease prevalence in recent centuries. Nonetheless, vaccine refusal has increased in recent years, with complacency associated with reductions in disease prevalence highlighted as an important contributor. We exploit a natural experiment in Glasgow at the beginning of the twentieth century to investigate whether prior local experience of an infectious disease matters for vaccination decisions. Our study is based on smallpox surveillance data and administrative records of parental refusal to vaccinate their infants. We analyse variation between administrative units of Glasgow in cases and deaths from smallpox during two epidemics over the period 1900–1904, and vaccine refusal following its legalization in Scotland in 1907 after a long period of compulsory vaccination. We find that lower local disease incidence and mortality during the epidemics were associated with higher rates of subsequent vaccine refusal. This finding indicates that complacency influenced vaccination decisions in periods of higher infectious disease risk, responding to local prior experience of the relevant disease, and has not emerged solely in the context of the generally low levels of infectious disease risk of recent decades. These results suggest that vaccine delivery strategies may benefit from information on local variation in incidence.
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影响因子：
29.9
作者：
Amin, Avnika B.;Bednarczyk, Robert A.;Omer, Saad B.
通讯作者：
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影响因子：
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作者：
Attwell, Katie;Ward, Paul R.;Leask, Julie
通讯作者：
Leask, Julie
DOI：
10.1146/annurev-economics-080217-053402
发表时间：
2018-01-01
期刊：
ANNUAL REVIEW OF ECONOMICS, VOL 10
影响因子：
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作者：
Abadie, Alberto;Cattaneo, Matias D.
通讯作者：
Cattaneo, Matias D.
影响因子：
1
作者：
Durbach, N
通讯作者：
Durbach, N
影响因子：
1.4
作者：
HARDY, A
通讯作者：
HARDY, A