Replicates in high dimensions, with applications to latent variable graphical models.
Replicates in high dimensions, with applications to latent variable graphical models.
复制标题
在高维中复制,并应用于潜在变量图形模型。
DOI:
10.1093/biomet/asw050
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发表时间:
2016-12
期刊:
影响因子:
2.7
通讯作者:
Liu H
中科院分区:
文献类型:
--
作者:
Tan KM;Ning Y;Witten DM;Liu H
In classical statistics, much thought has been put into experimental design and data collection. In the high-dimensional setting, however, experimental design has been less of a focus. In this paper, we stress the importance of collecting multiple replicates for each subject in this setting. We consider learning the structure of a graphical model with latent variables, under the assumption that these variables take a constant value across replicates within each subject. By collecting multiple replicates for each subject, we are able to estimate the conditional dependence relationships among the observed variables given the latent variables. To test the null hypothesis of conditional independence between two observed variables, we propose a pairwise decorrelated score test. Theoretical guarantees are established for parameter estimation and for this test. We show that our proposal is able to estimate latent variable graphical models more accurately than some existing proposals, and apply the proposed method to a brain imaging dataset.
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DOI:
10.1111/rssb.12123
发表时间:
2016-03-01
期刊:
Journal of the Royal Statistical Society. Series B, Statistical methodology
影响因子:
--
作者:
Qiu H;Han F;Liu H;Caffo B
通讯作者:
Caffo B
影响因子:
2.7
作者:
Voorman A;Shojaie A;Witten D
通讯作者:
Witten D
影响因子:
4.5
作者:
Liu, Han;Han, Fang;Wasserman, Larry
通讯作者:
Wasserman, Larry
影响因子:
4.5
作者:
Chandrasekaran, Venkat;Parrilo, Pablo A.;Willsky, Alan S.
通讯作者:
Willsky, Alan S.
影响因子:
3.7
作者:
Peng J;Wang P;Zhou N;Zhu J
通讯作者:
Zhu J