GABA-mediated baroreceptor inhibition of reticulospinal neurons.
GABA-mediated baroreceptor inhibition of reticulospinal neurons.
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GABA 介导的压力感受器抑制网状脊髓神经元。
DOI：
10.1152/ajpregu.1985.249.6.r672
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Guyenet,PG
中科院分区：
文献类型：
--
作者：
Sun,MK;Guyenet,PG
在氟烷麻醉大鼠副巨细胞外侧核（PGCL）面后部分，共记录到45个细胞出现脊髓突起、脉冲同步放电和对动脉压变化极度敏感。每个测试单元都被γ -氨基丁酸（GABA）、甘氨酸和牛磺酸的离子吸附作用抑制，并被谷氨酸或GABA受体拮抗剂双库兰甲氧基醚激发。甲氧基二环碱能拮抗GABA的抑制作用，士的宁不能拮抗；士的宁消除了甘氨酸的影响，但二胡兰对其没有影响。离子导电应用二胡碱完全拮抗由动脉压升高引起的单位活性的时间锁定性降低，而士的宁则无效。1-谷氨酸的剂量比二胡兰对单位放电率的增加更大，但并没有显著改变与动脉压升高相关的抑制程度。由此可见，GABA或其相关物质介导了动脉压力感受器激活引起的PGCL网状脊髓神经元的抑制。
A total of 45 cells with spinal projections, pulse-synchronous discharges, and extreme sensitivity to changes in arterial pressure were recorded in the retrofacial portion of nucleus paragigantocellularis lateralis (PGCL) in halothane-anesthetized rats. Every unit tested was inhibited by iontophoretic applications of gamma-aminobutyric acid (GABA), glycine, and taurine and excited by glutamate or the GABA receptor antagonist bicuculline methiodide. The inhibitory effect of GABA was antagonized by bicuculline methiodide but not by strychnine; the effect of glycine was eliminated by strychnine but unaffected by bicuculline. Iontophoretically applied bicuculline completely antagonized the time-locked reduction in unit activity resulting from increases in arterial pressure while strychnine was ineffective. 1-Glutamate, applied in a dose that produced a larger increase in the unit discharge rate than bicuculline, did not significantly alter the magnitude of the inhibition associated with increases in arterial pressure. It is concluded that GABA or a related substance mediates the inhibition of PGCL reticulospinal neurons resulting from the activation of arterial baroreceptors.