piRNAs and Their Functions in the Brain.
piRNAs and Their Functions in the Brain.
复制标题
DOI：
10.1080/09723757.2016.11886278
复制
发表时间：
2016-03
影响因子：
0.1
通讯作者：
Luo X
中科院分区：
文献类型：
--
作者：
Zuo L;Wang Z;Tan Y;Chen X;Luo X
Piwi相互作用RNA（piRNA）是一类长度为24-32个核苷酸的非编码RNA。它们在长度、表达模式、丰度和基因组组织方面与micro-RNAs（miRNAs）相比表现出明显的差异。在每个物种中存在数十万个独特的皮尔纳序列。许多piRNA已被鉴定并保存在公共数据库中。由于piRNA最初是在生殖系中发现和充分研究的，一些其他研究已经报道了piRNA在包括神经元在内的体细胞中的存在。本文综述了piRNA的共同特征、生物起源、功能和分布，并总结了其在脑中的具体功能。这一综述可能为脑疾病的研究提供新的思路和方向。
Piwi-interacting RNAs (piRNAs) are the non-coding RNAs with 24–32 nucleotides (nt). They exhibit stark differences in length, expression pattern, abundance, and genomic organization when compared to micro-RNAs (miRNAs). There are hundreds of thousands unique piRNA sequences in each species. Numerous piRNAs have been identified and deposited in public databases. Since the piRNAs were originally discovered and well-studied in the germline, a few other studies have reported the presence of piRNAs in somatic cells including neurons. This paper reviewed the common features, biogenesis, functions, and distributions of piRNAs and summarized their specific functions in the brain. This review may provide new insights and research direction for brain disorders.