Recurrent bullous eruption of the feet.
Recurrent bullous eruption of the feet.
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DOI：
10.1111/j.1365-2133.1938.tb10576.x
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发表时间：
1938-01-01
影响因子：
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通讯作者：
Cockayne, EA
中科院分区：
文献类型：
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作者：
Cockayne, EA
1935年7月1日，H。麦考马克好心地派了一个家庭的三个成员来看我，他们都在米德尔塞克斯医院的门诊部，一个母亲和她的两个儿子，他们都有很大的脓包，破碎的或有清晰的内容物，位于脚底和脚的内外两侧。公牛只在温暖的天气出现，并引起热和不适的感觉。没有疤痕，摩擦脚底、两侧和足背也没有新的伤口出现。患者的一般健康状况和体质良好。毛发、指甲、牙齿和粘膜正常，无皮肤划痕症。没有注意到足部或身体其他部位过度出汗，母亲也不认为发生了这种情况。这位33岁的母亲说，她很容易擦伤，她的两个受影响的孩子比正常的孩子更容易擦伤。她提供了一份病史，说这个家族连续四代中有六个甚至七个成员患过同样的病，而且所有患病的成员都只在脚上出现过牛斑，而且只有在天气暖和的时候才出现，所有病例的发病年龄都在1岁到2岁之间。她的父亲，刘易斯，是威尔士人;她的母亲，哈蒙德，54岁，二。1岁，她的外祖父利森二世是英国人，住在伦敦。她是独生女;她母亲的兄弟，二。3，谁也有同样的条件，没有问题，在伟大的战争中死亡，和她母亲的妹妹，二。4、正常，未婚。她相信她的另一个哥哥，二。2、本来有条件，但她已经和他失去了联系。她的长子，11岁，四。1，是正常的，但她的另外两个儿子，年龄分别为7岁和2岁3个月，四。2、3例均为大疱性皮疹。MacCormac医生诊断为大疱性表皮炎，但这是一种非常不典型的形式。在大疱性表皮病中，单纯性大疱由于创伤而出现在身体的任何部位，并发生在任何部位。
ON July 1st, 1935, Dr. H. MacCormac kindly sent three members of a family who were attending his Out-Patient Department at the Middlesex Hospital to see me. All three, a mother and her two sons, had large buUae, broken or with clear contents, situated on the soles and on the inner and outer sides of the feet. The bullse appeared only in warm weather, and caused a sensation of heat and discomfort. There were no scars, and rubbing the soles, sides and dorsum of the feet caused no fresh buUae to appear. The general health and physique of the patients were good. The hair, nails, teeth and mucous membranes were normal and there was no dermatographism. No excessive sweating of the feet or other parts of the body w^ as noticed, nor did the mother think it occurred. The mother, aged 33 years, said that she bruised rather easily, and that her two affected children bruised more readily than the normal one. She gave a history that the same condition had occurred in six and probably in seven members of the family in four successive generations, and that in all the affected members bullse had appeared only on the feet, and then only when the weather was w^ arm. The onset in all cases was between the age of 1 and 2 years. Her father, Lewis, is Welsh; her mother, Hammond, aged 54 years, II. 1, and her maternal grandfather, Leeson, II, are English and live in London. She is an only child; her mother's brother, II. 3, who had the same condition, died without issue in the Great War, and her mother's sister, II. 4, was normal and unmarried. She believes that her other brother, II. 2, had the condition, but she has lost touch with him. Her eldest son, aged 11 years, IV. 1, is normal, but her two other sons, aged 7 years and 2 years and 3 months respectively, IV. 2 and 3, both have the bullous eruption. Dr. MacCormac diagnosed the condition as epidermolysis bullosa, but it is a very atypical form. In epidermolysis bullosa simplex bullse appear on any part of the body as a result of trauma and occur at any