Deficits in long-term retention of learned motor skills in patients with cortical or subcortical degeneration
Deficits in long-term retention of learned motor skills in patients with cortical or subcortical degeneration
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DOI：
10.1016/j.neuropsychologia.2004.03.012
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发表时间：
2004-01-01
期刊：
影响因子：
2.6
通讯作者：
Tagaya, H
中科院分区：
文献类型：
--
作者：
Mochizuki-Kawai, H;Kawamura, M;Tagaya, H
我们调查了皮质（阿尔茨海默病，AD）和皮质下（进行性核上性麻痹，PSP；帕金森病，PD）变性患者新技能的获得和长期保留情况。 PD和PSP患者的运动技能任务表现通过训练得到改善，但这种改善在几个月内消失，而AD患者则保留所学技能3-18个月。我们的实验结果表明，皮质下功能障碍会导致新学到的运动技能的保留缺陷。我们目前的研究表明，正常的纹状体对于持久运动技能的形成是必要的，并且纹状体作为运动技能巩固系统发挥着重要作用。 (C) 2004 Elsevier Ltd. 保留所有权利。
We investigated the acquisition and long-term retention of new skills in patients with cortical (Alzheimer's disease, AD) and subcortical (progressive supranuclear palsy, PSP; Parkinson's disease, PD) degeneration. The motor skill task performance of the PD and PSP patients improved with training, but the improvement disappeared within a few months, whereas AD patients retained learned skills for 3-18 months. The results of our experiments show that subcortical dysfunction induces a retention deficit for newly learned motor skills. Our present study suggests that a normal striatum is necessary for the formation of long-lasting motor skills, and that the striatum plays an important role as a motor skill consolidation system. (C) 2004 Elsevier Ltd. All rights reserved.