Comparative rates of metabolism of pipecolic acid in several animal species.
Comparative rates of metabolism of pipecolic acid in several animal species.
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DOI：
10.1016/0305-0491(82)90351-0
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
J. Dancis;J. Hutzler
中科院分区：
文献类型：
--
作者：
J. Dancis;J. Hutzler
1. The rate of metabolism of pipecolic acid, measured in liver and kidney, varied 1000 fold among 10 animal species. Degradation of L-pipecolic acid by kidney in rat and mouse was 0.11 and 0.31 pmoles/min/mg protein, respectively; in monkey and human. 3.0 and 6.5; in guinea-pig and rabbit 101 and 106. 2. Activity with D-pipecolic acid was consistently 50-60% higher than the L-isomer except in the rabbit. 3. Degradation of L-lysine presumably through the saccharopine-alpha-aminoadipic acid pathway, was effective in all species, contrasting with the variable performance in the pipecolic acid-alpha-aminoadipic acid pathway.
