The emerging roles of microRNAs in CNS injuries.
The emerging roles of microRNAs in CNS injuries.
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DOI：
10.1038/nrneurol.2013.67
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发表时间：
2013-06
影响因子：
38.1
通讯作者：
Kessler, John A.
中科院分区：
文献类型：
--
作者：
Bhalala, Oneil G.;Srikanth, Maya;Kessler, John A.
中枢神经系统受伤的后果是深刻的，持续的，导致个人患者和社会的现有治疗方法。了解损伤后的细胞和分子变化。翻译并在正常的中枢神经系统发育和功能以及疾病中具有关键作用。网络，可以揭示受影响的途径，这些途径可能无法使用传统技术，例如基因敲入或敲除方法或mRNA微阵列这篇综述，我们讨论了miRNA微阵列研究的发现，脊髓损伤，创伤性脑损伤和中风，以及使用基因本体论算法来识别这种损伤后分子和细胞变化的全局模式。基于miRNA的疗法的状态及其改善中枢神经系统损伤患者功能结果的潜力。
The consequences of injuries to the CNS are profound and persistent, resulting in substantial burden to both the individual patient and society. Existing treatments for CNS injuries such as stroke, traumatic brain injury and spinal cord injury have proved inadequate, partly owing to an incomplete understanding of post-injury cellular and molecular changes. MicroRNAs (miRNAs) are RNA molecules composed of 20–24 nucleotides that function to inhibit mRNA translation and have key roles in normal CNS development and function, as well as in disease. However, a role for miRNAs as effectors of CNS injury has recently emerged. Use of bioinformatics to assess the mRNA targets of miRNAs enables high-order analysis of interconnected networks, and can reveal affected pathways that may not be identifiable with the use of traditional techniques such as gene knock-in or knockout approaches, or mRNA microarrays. In this Review, we discuss the findings of miRNA microarray studies of spinal cord injury, traumatic brain injury and stroke, as well as the use of gene ontological algorithms to discern global patterns of molecular and cellular changes following such injuries. Furthermore, we examine the current state of miRNA-based therapies and their potential to improve functional outcomes in patients with CNS injuries.
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