Behavioral State Regulation of Dendrodendritic Synaptic Inhibition in the Olfactory Bulb
Behavioral State Regulation of Dendrodendritic Synaptic Inhibition in the Olfactory Bulb
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DOI：
10.1523/jneurosci.1576-08.2008
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发表时间：
2008-09
期刊：
影响因子：
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通讯作者：
Y. Tsuno;H. Kashiwadani;K. Mori
中科院分区：
文献类型：
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作者：
Y. Tsuno;H. Kashiwadani;K. Mori
行为状态调节信息在局部神经元回路中的处理方式。在这里，我们问是否在嗅球树突突触的相互作用随大脑和行为状态。为了研究状态依赖性的树-树突触传递的变化，我们监测了嗅球的场电位反应的变化，麻醉和自由行为的大鼠。在麻醉大鼠，颗粒二尖瓣树突状突触抑制更大，更长的慢波出现在脑电图（慢波状态）比在快波状态。颗粒-二尖瓣抑制的状态依赖性交替变化受胆碱能系统调节。此外，自发振荡活动的局部场电位和周期性放电的僧帽细胞在嗅球的频率转移与新皮质脑状态的变化同步。自由行为的大鼠表现出多层次的变化，对应于不同的行为状态的树-树突触抑制，抑制是最大的慢波睡眠状态，并依次较小的浅睡眠，清醒的不动，清醒的运动状态。这些结果提供的证据表明，行为状态依赖性的胆碱能神经紧张的全球变化调节树突突触抑制和嗅球的信息处理模式。
Behavioral states regulate how information is processed in local neuronal circuits. Here, we asked whether dendrodendritic synaptic interactions in the olfactory bulb vary with brain and behavioral states. To examine the state-dependent change of the dendrodendritic synaptic transmission, we monitored changes in field potential responses in the olfactory bulb of urethane-anesthetized and freely behaving rats. In urethane-anesthetized rats, granule-to-mitral dendrodendritic synaptic inhibition was larger and longer when slow waves were present in the electroencephalogram (slow-wave state) than during the fast-wave state. The state-dependent alternating change in the granule-to-mitral inhibition was regulated by the cholinergic system. In addition, the frequency of the spontaneous oscillatory activity of local field potentials and periodic discharges of mitral cells in the olfactory bulb shifted in synchrony with shifts in the neocortical brain state. Freely behaving rats showed multilevel changes in dendrodendritic synaptic inhibition that corresponded to diverse behavioral states; the inhibition was the largest during slow-wave sleep state, and successively smaller during light sleep, awake immobility, and awake moving states. These results provide evidence that behavioral state-dependent global changes in cholinergic tone modulate dendrodendritic synaptic inhibition and the information processing mode in the olfactory bulb.