REVERSIBLE TUBULAR PROTEINURIA PRECEDES MICROALBUMINURIA AND CORRELATES WITH THE METABOLIC STATUS IN DIABETIC CHILDREN
REVERSIBLE TUBULAR PROTEINURIA PRECEDES MICROALBUMINURIA AND CORRELATES WITH THE METABOLIC STATUS IN DIABETIC CHILDREN
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DOI：
10.1007/bf00861555
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发表时间：
1993-02-01
影响因子：
3
通讯作者：
GUSMANO, R
中科院分区：
文献类型：
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作者：
GINEVRI, F;PICCOTTI, E;GUSMANO, R
本文对53例胰岛素依赖型糖尿病（IDDM）患儿的早期肾小管改变进行了研究，其中32例每隔6个月定期随访3年。尿视黄醇结合蛋白（RBP），β 2-微球蛋白和刷状缘抗原（BBA）（由单克隆酶免疫测定）的水平被视为指标的功能和细胞肾小管的变化，尿白蛋白被认为是肾小球病变的早期标志物。与368名正常儿童相比，IDDM儿童的肾小管改变的所有指标均较高，而蛋白尿无变化。然而，在随访期间，尿BBA水平变化很大，在32例定期随访的IDDM患者中，有25例至少有一次出现BBA病理值，随后恢复正常。代谢改变被认为是这种变异性的主要原因，因为尿BBA和果糖胺之间存在高度的统计学相关性（P
Early tubular alterations were studied in 53 children with insulin-dependent diabetes mellitus (IDDM), 32 of whom were followed at regular 6-monthly intervals for 3 years. The urinary levels of retinol-binding protein (RBP), beta2-microglobulin and brush border antigens (BBA) (determined by monoclonal enzyme immunoassay) were taken as indices of functional and cellular tubular alterations; urinary albumin was considered an early marker of glomerular alterations. All indices of tubular alterations were higher in IDDM children than in 368 normal children, while albuminuria was unchanged. Urinary levels of BBA, however, varied widely during follow-up, with 25 of the 32 IDDM patients who were followed at regular intervals having pathological values for BBA on at least one occasion, followed by normalization. Metabolic alteration was found to be the main cause of this variability, since a high statistical correlation was found between urinary BBA and fructosamine (P