A heat-generating bioactive glass-ceramic for hyperthermia.
A heat-generating bioactive glass-ceramic for hyperthermia.
复制标题
用于热疗的发热生物活性玻璃陶瓷。
DOI：
10.1002/jab.770020303
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
M. Oka
中科院分区：
文献类型：
--
作者：
K. Ohura;M. Ikenaga;T. Nakamura;T. Yamamuro;Y. Ebisawa;T. Kokubo;Y. Kotoura;M. Oka
将化学组成为CaO（29.0）、SiO2（31.0）、Fe 2 O3（40.0）、B 2 O3（3.0）、P2 O 5（3.0）的玻璃板以5 ℃/min的速率加热至1050 ℃，然后冷却至实验室温度。所得到的含有磁铁矿和硅灰石晶体的玻璃陶瓷显示出高饱和磁化强度。用兔胫骨评价了这种新型玻璃陶瓷与骨组织的结合能力，并与相同成分的玻璃进行了比较。该微晶玻璃在植入后8周内表面形成一层富钙磷层，并与骨结合紧密。然而，在25周时，玻璃没有形成这种富含钙、磷的层，也没有与骨结合。采用最大热膨胀系数法研究了该微晶玻璃的骨热性能。300奥斯特100千赫磁场填充在兔胫骨中的玻璃陶瓷颗粒将整个周围骨加热到42摄氏度以上，并保持该温度30分钟。生物活性陶瓷增强了骨组织的机械强度。此外，这种发热生物活性玻璃陶瓷可用于骨肿瘤的热疗。
Glass plates of the chemical composition: CaO (29.0), SiO 2 (31.0), Fe 2O 3 (40.0), B 2O 3 (3.0), P 2O 5 (3.0) in weight ratio were heated to 1050 degrees C at a rate of 5 degrees C/min and then cooled to laboratory temperature. The resulting glass-ceramic containing magnetite and wollastonite crystals showed high-saturation magnetization. The bonding ability of this new glass-ceramic to bone tissue was evaluated using rabbit tibiae, and compared with glass of the same composition. This glass-ceramic formed a Ca, P-rich layer on its surface and bonded tightly with bone within 8 weeks of implantation. However, the glass did not form this Ca, P-rich layer, nor had it bonded with bone at 25 weeks. The bone-heating ability of this glass-ceramic was investigated by applying a max. 300-Oe, 100-kHz magnetic field. The granules of the glass-ceramic filled in the rabbit tibiae heated the whole surrounding bone to more than 42 degrees C and maintained this temperature for 30 min. Bioactive ceramics reinforce the mechanical strength of bone tissue. Furthermore, this heat-generating bioactive glass-ceramic can be used for hyperthermic treatment of bone tumors.