RISK OF BREAST-CANCER FOLLOWING LOW-DOSE RADIATION EXPOSURE
RISK OF BREAST-CANCER FOLLOWING LOW-DOSE RADIATION EXPOSURE
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DOI：
10.1148/131.3.589
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发表时间：
1979-01-01
期刊：
影响因子：
19.7
通讯作者：
TOKUNAGA, M
中科院分区：
文献类型：
--
作者：
BOICE, JD;LAND, CE;TOKUNAGA, M
根据对多次胸部透视检查的肺结核患者、接受放射治疗的乳腺炎患者和原子弹爆炸幸存者的调查，研究了辐射照射后患乳腺癌的风险。青少年时期受辐射者的风险显然最大，尽管所有年龄段的辐射都有一定的风险。在所有研究中，剂量-反应关系与线性一致。在原子弹爆炸幸存者中，剂量低于0.5戈伊（50拉德）的辐射风险的直接证据是显而易见的。分离似乎并没有减少风险，也没有时间，因为曝光（即使经过45年的观察）。暴露与放射性乳腺癌临床表现之间的间隔可能由激素或其他年龄相关因素介导，但与剂量无关。所有研究中的特定风险估计值非常相似。20岁以后受到辐射的美国妇女的最佳风险估计是6.6个多余癌症/104 WY-Gy（106 WY-rad）。
Risk of breast cancer following radiation exposure was studied, based on surveys of tuberculosis patients who had multiple fluoroscopic examinations of the chest, mastitis patients given radiotherapy and atomic [A] bomb survivors. The risk apparently is greatest for persons exposed as adolescents, although exposure at all ages carries some risk. The dose-response relationship was consistent with linearity in all studies. Direct evidence of radiation risk at doses under 0.5 Gy (50 rad) is apparent among A-bomb survivors. Fractionation does not appear to diminish risk, nor does time since exposure (even after 45 yr of observation). The interval between exposure and the clinical appearance of radiogenic breast cancer may be mediated by hormonal or other age-related factors but is unrelated to dose. Age-specific absolute risk estimates for all studies are remarkably similar. The best estimate of risk among American women exposed after age 20 is 6.6 excess cancers/104 WY-Gy (106 WY-rad).