Review of hepatitis B therapeutics.
Review of hepatitis B therapeutics.
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DOI:
10.1086/656624
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发表时间:
2010-11-15
期刊:
影响因子:
--
通讯作者:
Thio CL
中科院分区:
文献类型:
--
作者:
Bhattacharya D;Thio CL
There are currently seven approved therapies for chronic hepatitis B infection, an increase from just three agents five years ago. This review will focus on the pharmacology, potency, and adverse events associated with immunomodulatory agents and nucleos(t)ide analogs, with an emphasis on targets of therapy within the hepatitis B lifecycle. We will also offer guidelines for the use of available anti-HBV agents and review the emerging challenges in hepatitis B management, including HBV drug resistance, its management, and the potential role of combination therapy.
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