Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal - A randomized treatment trial
Symptom-triggered vs fixed-schedule doses of benzodiazepine for alcohol withdrawal - A randomized treatment trial
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DOI：
10.1001/archinte.162.10.1117
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发表时间：
2002-05-27
影响因子：
--
通讯作者：
Yersin, B
中科院分区：
文献类型：
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作者：
Daeppen, JB;Gache, P;Yersin, B
背景：在酒精戒断中，固定剂量的苯二氮卓类药物通常被推荐作为一线药理学方法。本研究确定了在酒精戒断治疗期间，个体化治疗方案对苯二氮卓类药物给药量和使用持续时间的益处。方法：我们进行了一项前瞻性，随机，双盲，对照试验，包括117名连续的酒精依赖患者，根据精神疾病诊断和统计手册，第四版，在瑞士的洛桑和日内瓦大学医院接受酒精治疗。患者被随机分为2组：（1）56例患者接受奥沙西泮治疗，以应对酒精戒断体征的发展（酒精触发），（2）61例患者接受奥沙西泮治疗，每6小时一次，根据需要增加剂量（固定时间表）。使用酒精戒断的标准化测量来确定第1组中奥沙西泮和第2组中额外奥沙西泮的给药。结果：触发组有22例（39%）患者服用奥沙西泮，固定时间组100%服用奥沙西泮（P
Background: In alcohol withdrawal, fixed doses of benzodiazepine are generally recommended as a first-line pharmacologic approach. This study determines the benefits of an individualized treatment regimen on the quantity of benzodiazepine administered and the duration of its use during alcohol withdrawal treatment.Methods: We conducted a prospective, randomized, double-blind, controlled trial including 117 consecutive patients with alcohol dependence, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, entering an alcohol treatment program at both the Lausanne and Geneva university hospitals, Switzerland. Patients were randomized into 2 groups: (1) 56 were treated with oxazepam in response to the development of signs of alcohol withdrawal (symptom-triggered) and (2) 61 were treated with oxazepam every 6 hours with additional doses as needed (fixed-schedule). The administration of oxazepam in group 1 and additional oxazepam in group 2 was determined using a standardized measure of alcohol withdrawal. The main outcome measures were the total amount and duration of treatment with oxazepam, the incidence of complications, and the comfort level.Results: A total of 22 patients (39%) in the symptom-triggered group were treated with oxazepam vs 100% in the fixed-schedule group (P