Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications
Sensitive interferometric detection of ultrasound for minimally invasive clinical imaging applications
复制标题
DOI：
10.1002/lpor.201300204
复制
发表时间：
2014-05-01
影响因子：
11
通讯作者：
Ntziachristos, Vasilis
中科院分区：
文献类型：
--
作者：
Rosenthal, Amir;Kellnberger, Stephan;Ntziachristos, Vasilis
小型化的超声光学探测器代表着一种很有前途的替代压电技术的方法，并可能使新的微创临床应用成为可能，特别是在光声成像领域。然而，到目前为止，这种探测器的使用仅限于受控的实验室环境，并且还没有在存在机械干扰的情况下得到证明，这在临床成像场景中很常见。此外，检测灵敏度受到激光噪声的固有限制，这阻碍了光纤等传感元件的使用，因为光纤对超声波的响应较弱。在这项工作中，引入了相干恢复脉冲干涉测量(CRPI)-一种新的干涉传感范例，其中散粒噪声受限的灵敏度可以在稳健操作的同时实现。CRPI采用基于光纤的谐振器，比传统的15 MHz血管内超声探头的灵敏度高一个数量级以上。光学探测器的性能在小型化的全光学光声成像导管中得到展示。
Miniaturized optical detectors of ultrasound represent a promising alternative to piezoelectric technology and may enable new minimally invasive clinical applications, particularly in the field of optoacoustic imaging. However, the use of such detectors has so far been limited to controlled lab environments, and has not been demonstrated in the presence of mechanical disturbances, common in clinical imaging scenarios. Additionally, detection sensitivity has been inherently limited by laser noise, which hindered the use of sensing elements such as optical fibers, which exhibit a weak response to ultrasound. In this work, coherence-restored pulse interferometry (CRPI) is introduced - a new paradigm for interferometric sensing in which shot-noise limited sensitivity may be achieved alongside robust operation. CRPI is implemented with a fiber-based resonator, demonstrating over an order of magnitude higher sensitivity than that of conventional 15MHz intravascular ultrasound probes. The performance of the optical detector is showcased in a miniaturized all-optical optoacoustic imaging catheter.