Neuroimaging: visualising the brain in pain
Neuroimaging: visualising the brain in pain
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DOI：
10.1007/s10072-007-0760-x
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发表时间：
2007-05-01
影响因子：
3.3
通讯作者：
May, A.
中科院分区：
文献类型：
--
作者：
May, A.
实验和临床疼痛的神经影像学彻底改变了我们对疼痛生理反应的理解，并为更好地理解慢性疼痛综合征的病理生理学铺平了道路。对疼痛感觉辨别维度的中心机制的广泛研究揭示了参与疼痛传递和整合的皮质和皮质下大脑结构的复杂网络，即所谓的疼痛矩阵。尽管脑成像和药理学研究已经对可能参与慢性疼痛症状产生的电路产生了一些见解，但显然有必要对慢性疼痛的脑成像进行进一步的研究。然而，现代神经影像学表明，疼痛（和头痛）的慢性化涉及中枢和周围神经系统的功能和结构可塑性。
The neuroimaging of experimental and clinical pain has revolutionised our understanding of the physiological responses to pain and paved the way for a better understanding of the pathophysiology of chronic pain syndromes. Extensive research on the central mechanisms regarding the sensory-discriminative dimensions of pain have revealed a complex network of cortical and subcortical brain structures involved in the transmission and integration of pain, the so-called pain matrix. Although brain imaging and pharmacological studies have generated some insight into the circuitry that may be involved in the generation of chronic pain symptoms, further research into brain imaging of chronic pain is clearly warranted. However, modern neuroimaging suggests that the chronification of pain (and headaches) involves functional and structural plasticity of both the central and peripheral nervous system.