Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia
Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia
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DOI：
10.1176/appi.ajp.160.2.284
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发表时间：
2003-02-01
影响因子：
17.7
通讯作者：
Thakore, JH
中科院分区：
文献类型：
--
作者：
Ryan, MCM;Collins, P;Thakore, JH
目的：本研究调查了初治精神分裂症患者空腹糖耐量受损的患病率。方法：在这项横断面研究中，测量了 15 名男性和 11 名女性住院白人 DSM-IV 精神分裂症患者（平均年龄 = 33.6 岁）以及年龄和性别匹配的健康对照受试者的空腹血浆葡萄糖、胰岛素、血脂和皮质醇水平。患者和对照受试者在各种生活方式和人体测量指标方面也进行了匹配。结果：超过 15% 的初治精神分裂症首发患者存在空腹糖耐量受损，而健康志愿者则没有。与健康受试者相比，精神分裂症患者的空腹血浆血糖水平显着升高（健康受试者平均值=88.2 mg/dl，SD=5.4，而患者平均值=95.8 mg/dl，SD=16.9）、胰岛素（平均值=7.7 muu/ml，SD=3.7，对比平均值=9.8 muu/ml，SD=3.9）和皮质醇（平均值 = 303.2 nmol/L，SD = 10.5，对比平均值 = 499.4 nmol/L，SD = 161.4），并且根据稳态模型评估测量，胰岛素抵抗程度更高（健康受试者平均值 = 1.7，SD = 0.7，患者平均值 = 2.3，SD = 1.0）。结论：首次发作、未曾用药的精神分裂症患者的胰岛素抵抗受损与健康对照受试者相比，空腹葡萄糖耐量较高，胰岛素抵抗程度更高，血浆葡萄糖、胰岛素和皮质醇水平更高。
objective: This study examined the prevalence of impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia.Method: In this cross-sectional study, fasting plasma levels of glucose, insulin, lipids, and cortisol were measured in 15 male and 11 female hospitalized Caucasian patients with DSM-IV schizophrenia (mean age=33.6 years) and age- and sex-matched healthy comparison subjects. The patients and comparison subjects were also matched in terms of various life-style and anthropometric measures.Results: More than 15% of the drug-naive, first-episode patients with schizophrenia had impaired fasting glucose tolerance, compared to none of the healthy volunteers. Compared with the healthy subjects, the patients with schizophrenia had significantly higher fasting plasma levels of glucose (mean=88.2 mg/dl, SD=5.4, for the healthy subjects versus mean=95.8 mg/dl, SD=16.9, for the patients), insulin (mean=7.7 muu/ml, SD=3.7, versus mean=9.8 muu/ml, SD=3.9), and cortisol (mean=303.2 nmol/liter, SD=10.5, versus mean=499.4 nmol/liter, SD=161.4) and were more insulin resistant, as measured with homeostasis model assessment (mean= 1.7, SD=0.7, for the healthy subjects versus mean=2.3, SD=1.0, for the patients).Conclusions: First-episode, drug-naive patients with schizophrenia have impaired fasting glucose tolerance and are more insulin resistant and have higher levels of plasma glucose, insulin, and cortisol than healthy comparison subjects.