Meta-analysis of outcome studies in end-stage renal disease
Meta-analysis of outcome studies in end-stage renal disease
复制标题
终末期肾病结局研究的荟萃分析
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
S. Mujais
中科院分区：
文献类型：
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作者：
S. Ross;Esther W. Dong;M. J. Gordon;J. Connelly;M. Kvasz;M. Iyengar;S. Mujais
终末期肾病结局研究的荟萃分析。检查ESRD患者结局的研究来自多种来源（单中心、地区登记、国家登记等）。并提供了关于治疗方式选择对患者存活率的影响的不一致结果。为了尝试理解和解决这些差异，使用登记研究和非登记研究的已发表数据进行了详尽的文献检索和荟萃分析，以比较血液透析（HD）和腹膜透析（PD）患者的生存率。荟萃分析的结果基于来自82项文献非登记研究、55项文献登记研究和2份登记报告的数据，对模式转换、移植和脱落进行删失，未对病例组合进行调整，由于生存率和死亡率结局随所分析结局的数据来源和格式而变化，因此结果不确定。尽管有限的数据表明病例组合的差异可能导致生存结局的差异，但由于缺乏可用数据，无法调整病例组合（透析前共病）、透析充分性和其他重要患者水平协变量。这些发现强调了当前文献报告中固有的局限性，并强调需要比迄今为止报告ESRD结局结果的情况更统一、标准化和详细的方法。
Meta-analysis of outcome studies in end-stage renal disease. Studies examining outcomes in patients with ESRD are derived from a variety of sources (single center, regional registries, national registries, etc.) and provide discrepant results as to the impact of modality selection on patient survival. In an attempt to understand and resolve these discrepancies, an exhaustive literature search and meta-analysis were performed to compare survival in hemodialysis (HD) and peritoneal dialysis (PD) patients using published data from both registry studies and non-registry studies. Results of the meta-analysis, based on data from 82 literature non-registry studies, 55 literature registry studies, and two registry reports, censored for modality switches, transplants and dropouts and unadjusted for case mix, were inconclusive because survival and mortality outcomes varied with the data sources and formats for outcomes analyzed. Although limited data suggested that differences in case mix may contribute to differences in survival outcomes, adjustments for case mix (predialysis comorbid conditions), adequacy of dialysis, and other important patient level covariates were not possible because of the paucity of available data. These findings highlight the limitations inherent in current literature reports and underscore the need for more uniform, standardized, and detailed approaches than has hitherto been the case in reporting outcome findings in ESRD.
影响因子：
19.6
作者：
Held, PJ;Port, FK;Hakim, RM
通讯作者：
Hakim, RM
影响因子：
158.5
作者：
OWEN, WF;LEW, NL;LAZARUS, JM
通讯作者：
LAZARUS, JM