Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response
Mesenchymal Stem Cell Homing Into Intervertebral Discs Enhances the Tie2-positive Progenitor Cell Population, Prevents Cell Death, and Induces a Proliferative Response
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DOI：
10.1097/brs.0000000000003150
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发表时间：
2019-07
期刊：
影响因子：
3
通讯作者：
Sebastian Wangler;M. Peroglio;U. Menzel;L. Benneker;L. Haglund;D. Sakai;M. Alini;S. Grad
中科院分区：
文献类型：
--
作者：
Sebastian Wangler;M. Peroglio;U. Menzel;L. Benneker;L. Haglund;D. Sakai;M. Alini;S. Grad
补充数字内容可在文本中获得。间充质干细胞（MSC）从终板归巢至椎间盘（IVD）已被描述为替代椎间盘内应用途径。我们的研究结果表明，归巢的MSC增强Tie2阳性椎间盘祖细胞群，防止椎间盘细胞死亡，并诱导IVD细胞的增殖反应。
Supplemental Digital Content is available in the text Homing of mesenchymal stem cells (MSCs) from the endplate into the intervertebral disc (IVD) has been described as alternative intradiscal application route. Our findings indicate that the homed MSCs enhance the Tie2-positive disc progenitor cell population, prevent disc cell death, and induce a proliferative response in the IVD cells.