Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS): Technique, Targeting, and Considerations
Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS): Technique, Targeting, and Considerations
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DOI：
10.3791/58984
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发表时间：
2019-01-01
影响因子：
1.2
通讯作者：
Bikson, Marom
中科院分区：
文献类型：
--
作者：
Badran, Bashar W.;Yu, Alfred B.;Bikson, Marom
无创迷走神经刺激(VNS)可以通过一种新的神经调节技术--经皮耳迷走神经刺激(TaVNS)来实施。与颈部植入的VNS不同，taVNS是一种廉价的非手术方法，用于调节迷走神经系统。TaVNS很有吸引力，因为它允许快速翻译基础VNS研究，并作为一种安全、廉价和便携的神经刺激系统，用于未来中枢和外周疾病的治疗。介绍了TAVNS的背景和原理，以及电学和参数方面的考虑，适当的耳靶向和刺激电极的连接，通过感知阈值(PT)的确定进行个体化给药，以及TaVNS的安全给药。
Non-invasive vagus nerve stimulation (VNS) may be administered via a novel, emerging neuromodulatory technique known as transcutaneous auricular vagus nerve stimulation (taVNS). Unlike cervically-implanted VNS, taVNS is an inexpensive and non-surgical method used to modulate the vagus system. taVNS is appealing as it allows for rapid translation of basic VNS research and serves as a safe, inexpensive, and portable neurostimulation system for the future treatment of central and peripheral disease. The background and rationale for taVNS is described, along with electrical and parametric considerations, proper ear targeting and attachment of stimulation electrodes, individual dosing via determination of perception threshold (PT), and safe administration of taVNS.