Single and double A3-coupling (aldehyde-amine-alkyne) reaction catalyzed by an air stable copper(I)-phosphole complex
Single and double A3-coupling (aldehyde-amine-alkyne) reaction catalyzed by an air stable copper(I)-phosphole complex
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DOI：
10.1016/j.tetlet.2017.09.031
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发表时间：
2017-10-25
影响因子：
1.8
通讯作者：
Garcia, Juan M.
中科院分区：
文献类型：
--
作者：
Cammarata, Jose Ricardo;Rivera, Rocio;Garcia, Juan M.
一种对空气稳定的铜（I）-磷杂环戊烯配合物[CuCl（2，5-bis（2-thienyl）-1-phenylphosphole}（2）]（1）在单偶联和双偶联反应中用于制备单炔丙胺和双炔丙胺。测试了各种醛、胺和末端炔。这些反应中的大多数导致使用少量催化剂以良好产率形成预期的炔丙胺，并且避免使用纯化试剂和使用手套箱。(C)2017爱思唯尔有限公司版权所有。
An air stable copper(I)-phosphole complex, [CuCl(2,5-bis(2-thienyl)-1-phenylphosphole}(2)] (1), was utilized as a catalyst in single and double A(3)-coupling reactions for preparing mono- and bi-propargylamines. A variety of aldehydes, amines and terminal alkynes were tested. Most of these reactions led to formation of the expected propargylamines in good yields using low amounts catalyst and obviating both the use of purified reagents as employ of a glovebox. (C) 2017 Elsevier Ltd. All rights reserved.