Surfactant Protein-A Function: Knowledge Gained From SP-A Knockout Mice.
Surfactant Protein-A Function: Knowledge Gained From SP-A Knockout Mice.
复制标题
DOI：
10.3389/fped.2021.799693
复制
发表时间：
2021
影响因子：
2.6
通讯作者：
Floros J
中科院分区：
文献类型：
--
作者：
Depicolzuane L;Phelps DS;Floros J
肺表面活性物质蛋白在肺表面活性物质相关功能和先天免疫中具有多种作用。其中一种蛋白是表面活性蛋白A(SP-A)，它在表面活性物质相关的过程和宿主防御中发挥作用，也是本文的重点。SP-A与肺泡中的前哨宿主防御细胞--肺泡巨噬细胞(AM)相互作用，调节其在不同条件下的功能和表达谱，以及其他肺泡上皮细胞，如II型细胞。通过这些相互作用，SP-A对肺泡微环境产生影响。SP-A对表面活性物质的结构和功能也有重要影响。许多关于SP-A的功能及其在肺健康中的不同作用的了解都是从SP-A基因敲除(KO)小鼠实验中学到的，本文对此进行了综述。这项工作的绝大多数是通过感染模型完成的，这些模型本质上是细菌、病毒和真菌。其他模型也已被使用，包括博莱霉素诱导的肺损伤和臭氧诱导的氧化应激，无论是单独还是与感染剂、骨髓移植等联合使用。此外，研究SP-A对表面活性剂组成或结构的影响的模型也提供了重要的信息。SP-A似乎也在感染和/或氧化应激反应的性别差异所涉及的通路中发挥作用，以及在基线条件下。到目前为止，这是第一次对通过KO小鼠了解到的SP-A的功能提供全面的报告。
Pulmonary surfactant proteins have many roles in surfactant- related functions and innate immunity. One of these proteins is the surfactant protein A (SP-A) that plays a role in both surfactant-related processes and host defense and is the focus in this review. SP-A interacts with the sentinel host defense cell in the alveolus, the alveolar macrophage (AM), to modulate its function and expression profile under various conditions, as well as other alveolar epithelial cells such as the Type II cell. Via these interactions, SP-A has an impact on the alveolar microenvironment. SP-A is also important for surfactant structure and function. Much of what is understood of the function of SP-A and its various roles in lung health has been learned from SP-A knockout (KO) mouse experiments, as reviewed here. A vast majority of this work has been done with infection models that are bacterial, viral, and fungal in nature. Other models have also been used, including those of bleomycin-induced lung injury and ozone-induced oxidative stress either alone or in combination with an infectious agent, bone marrow transplantation, and other. In addition, models investigating the effects of SP-A on surfactant components or surfactant structure have contributed important information. SP-A also appears to play a role in pathways involved in sex differences in response to infection and/or oxidative stress, as well as at baseline conditions. To date, this is the first review to provide a comprehensive report of the functions of SP-A as learned through KO mice.
登录
查看更多内容
DOI：
10.1083/jcb.141.6.1301
发表时间：
1998-06-15
期刊：
The Journal of cell biology
影响因子：
--
作者：
Abbondanza C;Rossi V;Roscigno A;Gallo L;Belsito A;Piluso G;Medici N;Nigro V;Molinari AM;Moncharmont B;Puca GA
通讯作者：
Puca GA
DOI：
10.1152/ajplung.1994.267.5.l578
发表时间：
1994-11-01
影响因子：
4.9
作者：
GEERTSMA, MF;NIBBERING, PH;VANFURTH, R
通讯作者：
VANFURTH, R
DOI：
10.1164/ajrccm.160.6.9901117
发表时间：
1999-12-01
影响因子：
24.7
作者：
Greene, KE;Wright, JR;Martin, TR
通讯作者：
Martin, TR
影响因子：
9
作者：
Green ES;Arck PC
通讯作者：
Arck PC
影响因子：
7.3
作者：
Floros J;Thorenoor N;Tsotakos N;Phelps DS
通讯作者：
Phelps DS