A critical evaluation of oxygen disappearance during stop flow in the gerbil brain.
A critical evaluation of oxygen disappearance during stop flow in the gerbil brain.
复制标题
对沙鼠大脑停止流动期间氧气消失的关键评估。
DOI：
10.1080/01616412.1982.11739614
复制
发表时间：
1982
影响因子：
1.9
通讯作者：
Reneau,DD
中科院分区：
文献类型：
--
作者：
Martin,RM;HalseyJr,JH;Reneau,DD
在正常组织PO2和高压氧作用下，用氧微电极测量双侧颈动脉闭塞期间沙鼠大脑皮层的氧消失率。研究发现，由于血红蛋白结合氧的去饱和度，氧消失率 (ODR) 很大程度上取决于闭塞时的 PO2。当组织 PO2 升高到足以使血红蛋白饱和的水平时，ODR 反映了耗氧率，计算范围为 1.6–7.4 cc O2/100 cc 组织分钟。研究发现，在许多情况下，PO2 的下降并不完全线性至零，而是由线性阶段和随后的斜率下降期组成。我们相信这个变化斜率的阶段代表着耗氧率的下降。这种减少的确切性质尚不清楚，但可能是由于循环停滞而对代谢物积累的抑制反应。
The rate of oxygen disappearance from the gerbil cerebral cortex was measured during bilateral carotid artery occlusion with an oxygen rnicroelectrode at normal tissue PO2and under hyperbaric oxygenation. The oxygen disappearance rate (ODR) was found to be heavily dependent on the PO2at occlusion due to the desaturation of hemoglobin-bound oxygen. When the tissue PO2was elevated to a level high enough to saturate hemoglobin, the ODR reflected the oxygen consumption rate which was calculated to range from 1.6–7.4 cc O2/100 cc tissue-min. for ten barbiturate-anesthetized animals.The fall in PO2was found not to be totally linear to zero in many cases, but instead consisted of a linear phase followed by a period of decreasing slope. We believe this phase of changing slope represents a diminishing oxygen consumption rate. The exact nature of this decrease is not known but perhaps is an inhibitory response to the accumulation of metabolites as a result of the circulation arrest.