Myelin in cartilaginous fish.
Myelin in cartilaginous fish.
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DOI：
10.1016/j.brainres.2016.01.013
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发表时间：
2016-06-15
期刊：
影响因子：
2.9
通讯作者：
de Bellard ME
中科院分区：
文献类型：
--
作者：
de Bellard ME
髓磷脂可能是最令人着迷和创新的生物获取之一：一种胶质质膜紧紧地包裹在轴突上并将其绝缘。软骨鱼（软骨鱼）是脊椎动物的一大群，是现存最古老的有颌脊椎动物谱系之一。150年前的研究表明，它们是脊椎动物致密髓磷脂和主要粘附蛋白成功出现的根源。更重要的是，它们致密髓磷脂的超微结构与在四足动物中观察到的没有区别，第一个真正的髓磷脂碱性蛋白（MBP）和髓磷脂零蛋白（MPZ）似乎起源于软骨鱼或它们的祖先——平皮动物。因此，对它们髓磷脂形成的研究将为脊椎动物髓磷脂的进化提供新的见解。软骨鱼中枢神经系统（CNS）髓磷脂组成与周围神经系统（PNS）髓磷脂组成也非常相似。虽然它们缺乏像四足动物那样的真正的蛋白脂蛋白（PLP），但它们在髓磷脂中表达一种类似dm的蛋白质。
Myelin is probably one of the most fascinating and innovative biological acquisition: a glia plasma membrane tightly wrapped around an axon and insulating it. Chondrichthyans (cartilaginous fishes) form a large group of vertebrates, and they are among oldest extant jawed vertebrate lineage. It has been known from studies 150 years ago, that they are positioned at the root of the successful appearance of compact myelin and main adhesive proteins in vertebrates. More importantly, the ultrastructure of their compact myelin is indistinguishable from the one observed in tetrapods and the first true myelin basic protein (MBP) and myelin protein zero (MPZ) seem to have originated on cartilaginous fish or their ancestors, the placoderms. Thus, the study of their myelin formation would bring new insights in vertebrate’s myelin evolution. Chondrichthyans central nervous system (CNS) myelin composition is also very similar to peripheral nervous system (PNS) myelin composition. And while they lack true proteolipid protein (PLP) like tetrapods, they express a DM-like protein in their myelin.
影响因子：
1.7
作者：
Rotenstein, L.;Herath, K.;Gould, R. M.;de Bellard, M. E.
通讯作者：
de Bellard, M. E.