Characterization of the chemical components on the surface of different solids with electrospray-assisted laser desorption ionization mass spectrometry
Characterization of the chemical components on the surface of different solids with electrospray-assisted laser desorption ionization mass spectrometry
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DOI：
10.1002/rcm.3011
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发表时间：
2007-01-01
影响因子：
2
通讯作者：
Shiea, Jentaie
中科院分区：
文献类型：
--
作者：
Huang, Min-Zong;Hsu, Hsiu-Jung;Shiea, Jentaie
在这项研究中，我们证明了电喷雾辅助激光解吸电离（ELDI）质谱（MS）可以在环境条件下用于快速表征不同固体表面的主要化学成分。用ELDI-MS快速表征了(a)不同脂肪含量的干牛奶、(b)不同颜色区域的绘画、(c)光盘上的薄涂层、(d)药物片剂和(e)猪脑组织中的主要化学成分为质子化分子[M+H]（+）或碱化分子[M+Na]（+）。用正离子或负离子模式直接从干燥的样品溶液中检测合成聚合物和染料标准品的电离离子。FD&C红色染料的进一步结构信息是通过串联质谱（MS/MS）分析获得的，该分析使用了连接在ELDI源上的离子阱质谱分析仪。版权所有(C) 2007约翰威利父子有限公司
In this study we demonstrate that electrospray-assisted laser desorption ionization (ELDI) mass spectrometry (MS) can be used to rapidly characterize major chemical components on the surfaces of different solids under ambient conditions. The major chemical components in (a) dried milks with different fat contents, (b) different color-regions of a painting, (c) the thin coating on a compact disc, (d) drug tablets, and (e) porcine brain tissue were rapidly characterized as protonated molecules [M+H](+) or sodiated molecules [M+Na](+) by ELDI-MS with minimum sample pretreatment. The ionized ions of synthetic polymer and dye standards were detected directly from dried sample solutions using either positive or negative ion mode. Further structural information for the FD&C Red dye was obtained through tandem mass spectrometric (MS/MS) analysis using an ion trap mass analyzer attached to the ELDI source. Copyright (C) 2007 John Wiley & Sons, Ltd.