Changes in composition of mucin in the mucosa adjacent to carcinoma of the colon as compared with the normal: A biochemical investigation
Changes in composition of mucin in the mucosa adjacent to carcinoma of the colon as compared with the normal: A biochemical investigation
复制标题
与正常相比，结肠癌邻近粘膜中粘蛋白成分的变化：生化研究
DOI：
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发表时间：
1974
影响因子：
3.4
通讯作者：
K. B. Cooke
中科院分区：
文献类型：
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作者：
M. Filipe;K. B. Cooke
对15例结直肠癌手术标本进行了研究。从远离肿瘤的正常粘膜和从邻近肿瘤的肉眼可见的正常粘膜（“过渡”）刮取的刮片用于己糖胺、唾液酸和蛋白质的化学估计。已糖胺和唾液酸的存在被证实在正常和过渡粘膜。与正常相比，移行粘膜显示总己糖胺和唾液酸水平增加，这伴随着神经氨酸酶敏感性唾液酸的增加。目前的数据已与以前的组织化学和放射自显影研究进行了比较，它表明，在过渡性粘膜中描述的变化是转化代表的早期阶段的癌变。
Fifteen surgical specimens from patients with carcinoma of the colon and rectum were studied. Scrapings from normal mucosa distant from the tumour and from macroscopically normal mucosa adjacent to the tumour (`transitional') were used for chemical estimation of hexosamines, sialic acid, and proteins. The presence of hexosamines and sialic acid was confirmed in both normal and transitional mucosa. Transitional mucosa showed increased levels of total hexosamines and sialic acid as compared with the normal and this was accompanied by an increase in neuraminidase-sensitive sialic acids. The present data have been compared with previous histochemical and autoradiographic studies and it is suggested that the changes described in the transitional mucosa are transformations representing an early stage of carcinogenesis.