Basement Membranes in Development and Disease.
Basement Membranes in Development and Disease.
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DOI：
10.1016/bs.ctdb.2018.02.005
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发表时间：
2018
影响因子：
--
通讯作者：
Yamada KM
中科院分区：
文献类型：
--
作者：
Sekiguchi R;Yamada KM
基底膜是一种薄而致密的片状细胞外基质，具有针对不同组织和器官量身定做的显著不同的功能。其组成和结构的严格控制的时空变化有助于基底膜功能的多样性。这些不同的基底膜在整个动物生命过程中都会经历动态的变化，最明显的是在发育过程中。许多发育机制是由基底膜调节或调节的，通常是通过分子和机械过程的组合。一个特别重要的过程涉及细胞通过基底膜的迁移，因为它与疾病中的细胞入侵有关。虽然发育过程和疾病过程有一些相似之处，但两者的明显区别是疾病中细胞和细胞外基质的失调。基底膜与许多发育和疾病过程相关，是一个极其重要的研究领域，可以为生物学机制和创新治疗方法的开发提供新的见解。本文对线虫、黑腹果蝇和脊椎动物基底膜的发育和疾病动态进行了综述。
The basement membrane is a thin but dense, sheet-like specialized type of extracellular matrix that has remarkably diverse functions tailored to individual tissues and organs. Tightly controlled spatial and temporal changes in its composition and structure contribute to the diversity of basement membrane functions. These different basement membranes undergo dynamic transformations throughout animal life, most notably during development. Numerous developmental mechanisms are regulated or mediated by basement membranes, often by a combination of molecular and mechanical processes. A particularly important process involves cell transmigration through a basement membrane because of its link to cell invasion in disease. While developmental and disease processes share some similarities, what clearly distinguishes the two is dysregulation of cells and extracellular matrices in disease. With its relevance to many developmental and disease processes, the basement membrane is a vitally important area of research that may provide novel insights into biological mechanisms and development of innovative therapeutic approaches. Here we present a review of developmental and disease dynamics of basement membranes in Caenorhabditis elegans, Drosophila melanogaster, and vertebrates.
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影响因子：
64.5
作者：
Brose, K;Bland, KS;Kidd, T
通讯作者：
Kidd, T
影响因子：
6.9
作者：
Candiello, Joseph;Cole, Gregory J.;Halfter, Willi
通讯作者：
Halfter, Willi
影响因子：
2.7
作者：
Coles, EG;Gammill, LS;Bronner-Fraser, M
通讯作者：
Bronner-Fraser, M
DOI：
10.1083/jcb.201405099
发表时间：
2015-02-02
期刊：
The Journal of cell biology
影响因子：
--
作者：
Artym VV;Swatkoski S;Matsumoto K;Campbell CB;Petrie RJ;Dimitriadis EK;Li X;Mueller SC;Bugge TH;Gucek M;Yamada KM
通讯作者：
Yamada KM
DOI：
10.4103/1947-2714.92892
发表时间：
2012-01
期刊：
North American journal of medical sciences
影响因子：
--
作者：
Abreu-Velez AM;Howard MS
通讯作者：
Howard MS