Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus
Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus
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DOI：
10.1038/nn1250
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发表时间：
2004-06-01
影响因子：
25
通讯作者：
Lopiano, L
中科院分区：
文献类型：
--
作者：
Benedetti, F;Colloca, L;Lopiano, L
已知安慰剂给药会影响疼痛和帕金森病的大脑。在这里，我们表明，安慰剂治疗引起的活动减少，在安慰剂反应性帕金森病患者的丘脑底核的单个神经元。这些活性变化与临床改善密切相关;当临床安慰剂反应不存在时，活性未降低。
Placebo administration is known to affect the brain both in pain and in Parkinson disease. Here we show that placebo treatment caused reduced activity in single neurons in the subthalamic nucleus of placebo-responsive Parkinsonian patients. These changes in activity were tightly correlated with clinical improvement; no decrease in activity occurred when the clinical placebo response was absent.