Modeling segmental patterning in Drosophila:: Maternal and gap genes
Modeling segmental patterning in Drosophila:: Maternal and gap genes
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DOI：
10.1016/j.jtbi.2005.11.034
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发表时间：
2006-07-21
影响因子：
2
通讯作者：
Dilao, Rui
中科院分区：
文献类型：
--
作者：
Alves, Filipa;Dilao, Rui
我们提出了一个新的数学模型，描述了沿果蝇早期胚胎的前轴沿前后轴的母体和间隙蛋白分段图案的建立。该模型基于实验数据，并且不反复出现预定的激活阈值，在定性和定量上对母体和间隙蛋白的表达模式进行预测，以及由mRNA异位表达和某些损失引起的蛋白质表达模式功能突变。我们得出的结论是，胚胎的间隙基因节段性图案和胚胎的空间组织由三个主要因素确定：（1）母体双子体和TOT-SO mRNA在卵内的初始定位，以及随后的相应蛋白质的扩散； （2）遗传调节网络的结构； （3）保护法在建立非扩散蛋白质稳定和不均匀的空间分布中的作用。 （c）2005 Elsevier Ltd.保留所有权利。
We propose a new mathematical model describing the establishment of maternal and gap proteins segmental patterning along the antero-posterior axis of the Drosophila early embryo. This model is based on experimental data and, without recurring to pre-defined activation thresholds, predicts qualitatively and quantitatively the expression patterns of the maternal and gap proteins, as well as the expression patterns of proteins resulting from mRNA ectopic expression and from some loss-of-function mutations. We conclude that the gap genes segmental patterning and consequent spatial organization of the embryo is determined by three main factors: (1) the initial positioning of the maternal bicoid and tot-so mRNA inside the egg, and subsequent diffusion of the corresponding proteins; (2) the structure of the genetic regulatory network; (3) the role of conservation laws in the establishment of steady and non-uniform spatial distributions of non-diffusing proteins. (c) 2005 Elsevier Ltd. All rights reserved.