Influenza virus infections in infants
Influenza virus infections in infants
复制标题
DOI：
10.1097/00006454-199711000-00012
复制
发表时间：
1997-11-01
影响因子：
3.6
通讯作者：
Piedra, PA
中科院分区：
文献类型：
--
作者：
Glezen, WP;Taber, LH;Piedra, PA
研究背景重组感冒减毒活疫苗已被提出在儿童中进行普遍免疫。再次建议母亲接种流感疫苗应增加传染给婴儿的抗体量，并推迟主动免疫的需要。本研究探讨了流感的风险，在第一年的生活提供信息的时间开始主动免疫。在休斯顿家庭研究中，从出生到1岁的婴儿每周监测流感病毒感染。每隔4个月对血清标本进行感染证据检测。209名婴儿中有三分之一是在第一年感染的;大多数感染发生在生命的第二个6个月。在69例感染中，只有26例在6个月大之前被检测到，而在6个月大之后则有43例。更引人注目的是严重疾病集中在第一年的后半年; 9例中耳炎中有8例，11例下呼吸道疾病中有9例发生在较大的婴儿中。流感免疫应导致母体抗体滴度增加，加上出生后前6个月患流感的风险较低，因此可以在6个月后开始对儿童进行主动免疫。
Background Universal immunization of children with live attenuated cold recombinant vaccine has been proposed. The renewed recommendation for maternal immunization with influenza vaccine should increase the amount of antibody transmitted to the infant and postpone the need for active immunization. This study examines the risk of influenza during the first year of life to provide information about the time to initiate active immunization.Methods. Infants followed from birth to 1 year of age in the Houston Family Study were monitored weekly for influenza virus infection. Serum specimens were tested for evidence of infection at 4-month intervals.Results. One-third of 209 infants were infected during the first year; most of the infections occurred during the second 6 months of life. Only 26 of 69 infections were detected before 6 months of age compared with 43 afterward. More striking was the concentration of serious illnesses in the latter half of the first year; 8 of 9 otitis media episodes and 9 of 11 lower respiratory tract illnesses occurred in the older infants.Conclusions. The combination of increased maternal antibody titers that should result from influenza immunization and the lesser risk of influenza in the first 6 months of life allows initiation of active immunization of children after 6 months of age.