OVERACTIVE PREFRONTAL AND UNDERACTIVE MOTOR CORTICAL AREAS IN IDIOPATHIC DYSTONIA
OVERACTIVE PREFRONTAL AND UNDERACTIVE MOTOR CORTICAL AREAS IN IDIOPATHIC DYSTONIA
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DOI：
10.1002/ana.410370313
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发表时间：
1995-03-01
影响因子：
11.2
通讯作者：
BROOKS, DJ
中科院分区：
文献类型：
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作者：
CEBALLOSBAUMANN, AO;PASSINGHAM, RE;BROOKS, DJ
使用 (H2O)-O-15 和正电子发射断层扫描技术测量了 6 名特发性扭转肌张力障碍患者组和 6 名对照受试者的局部脑血流量。受试者在休息时以及用右手在自由选择的方向上进行有节奏的操纵杆移动时进行扫描。特发性扭转肌张力障碍患者的对侧外侧前运动皮层、吻侧辅助运动区、布罗德曼 8 区、前扣带回 32 区、同侧背外侧前额叶皮层和双侧豆状核表现出明显的过度活动。尾部辅助运动区、双侧感觉运动皮层、后扣带皮层和内侧顶叶皮层的活动明显不足。这些结果与特发性扭转肌张力障碍中纹状体额叶投射的不适当过度活动和运动执行区的活动受损相一致，并且可以解释这些患者中同时存在的肌张力障碍姿势和明显的运动迟缓。
Regional cerebral blood flow was measured using (H2O)-O-15 and positron emission tomography ina group of 6 patients with idiopathic torsion dystonia and in a group of 6 control subjects. Subjects were scanned while at rest and when performing paced joystick movements in freely chosen directions with the right hand. Patients with idiopathic torsion dystonia showed significant overactivity in the contralateral lateral premotor cortex, rostral supplementary motor area, Brodmann area 8, anterior cingulate area 32, ipsilateral dorsolateral prefrontal cortex, and bilateral lentiform nucleus. Significant underactivity was found in the caudal supplementary motor area, bilateral sensorimotor cortex, posterior cingulate, and mesial parietal cortex. These results are consistent with inappropriate overactivity of striato-frontal projections and impaired activity of motor executive areas in idiopathic torsion dystonia and may explain the simultaneous dystonic posturing and bradykinesia evident in these patients.