Organosulfur compounds from alliaceae in the prevention of human pathologies.
Organosulfur compounds from alliaceae in the prevention of human pathologies.
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DOI：
10.1016/j.biopha.2004.01.004
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发表时间：
2004-04
期刊：
影响因子：
--
通讯作者：
H. Tapiero;D. Townsend;K. Tew
中科院分区：
文献类型：
--
作者：
H. Tapiero;D. Townsend;K. Tew
血浆低密度脂蛋白 (LDL) 升高与心血管疾病 (CVD) 的发生之间存在密切关联。低密度脂蛋白（Ox-LDL）的氧化会促进血管功能障碍，增强活性氧等炎症介质的产生和释放，并导致动脉粥样硬化的发生和进展。此外，Ox-LDL 还能增强肿瘤坏死因子 (TNF-α)、白细胞介素 (IL)-6、花生四烯酸代谢物和一氧化氮 (NO) 的产生和释放，这些物质是导致包括癌症在内的各种人类病理的原因。来自葱科植物的有机硫化合物 (OSC) 可调节人类 T 细胞中的谷胱甘肽 (GSH) 氧化还原循环并抑制 NFκ-B 激活。此外，OSC 的生物活性包括抗氧化、抗菌、抗癌、抗动脉粥样硬化、免疫刺激和肝脏保护潜力。
A strong association between elevated plasma low-density-lipoprotein (LDL) and the development of cardiovascular diseases (CVD) has been established. Oxidation of LDL (Ox-LDL) promotes vascular dysfunction, enhances the production and release of inflammatory mediators such as reactive oxygen species and contribute to the initiation and progression of atherosclerosis. In addition, Ox-LDL enhances the production and release of tumor necrosis factor (TNF-α), interleukin (IL)-6, arachidonic acid metabolites and nitric oxide (NO) that are responsible for various human pathologies including cancer. Organosulfur compounds (OSC) from alliaceae modulate the glutathione (GSH) redox cycle and inhibits NFκ-B activation in human T cells. Furthermore, OSC bioactivities include antioxidant, antibacterial, anticarcinogenic, antiatherogenic, immunostimulatory, and liver protection potential.