Optogenetics and Translational Medicine
Optogenetics and Translational Medicine
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DOI：
10.1126/scitranslmed.3003101
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发表时间：
2013-03-20
影响因子：
17.1
通讯作者：
Boyden, Edward S.
中科院分区：
文献类型：
--
作者：
Chow, Brian Y.;Boyden, Edward S.
光遗传工具能够在体内通过光中介控制细胞的兴奋性和信号。通过操纵生物过程，科学家可以确定这些过程在完整的生物系统中扮演的角色，例如大脑。这种细胞水平的控制极大地影响了基础科学。在这里，我们讨论如何通过识别新的分子和电路水平的靶点将光遗传学工具转化为临床影响，并为定义的生化或细胞事件提供时间上的精确干预。
Optogenetic tools enable light-mediated control of cellular excitability and signaling in vivo. By manipulating biological processes, scientists can determine the roles played by these processes in intact biological systems, such as the brain. Such cellular-level control has greatly affected basic science. Here, we discuss how optogenetic tools might be translated into clinical impact through identification of new molecular and circuit-level targets and provide temporally precise interventions for defined biochemical or cellular events.