Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian Infections.
Importance of Lipopolysaccharide and Cyclic β-1,2-Glucans in Brucella-Mammalian Infections.
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DOI：
10.1155/2010/124509
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发表时间：
2010
影响因子：
3.4
通讯作者：
Ferguson GP
中科院分区：
文献类型：
--
作者：
Haag AF;Myka KK;Arnold MF;Caro-Hernández P;Ferguson GP
布鲁氏菌是最流行的人畜共患疾病之一：布鲁氏菌病的病原体。布鲁氏菌属物种的感染在农业中造成重大经济损失，导致受感染动物流产，并导致人类严重但很少致命的衰弱性疾病。布鲁氏杆菌属物种作为细胞内病原体持续存在，其设法有效地逃避宿主免疫系统的识别。布鲁氏菌细胞外膜中的糖修饰成分在其与宿主相互作用中起重要作用。与大肠杆菌LPS不同，布鲁氏菌脂多糖（LPS）不会触发宿主的先天免疫系统。布鲁氏菌产生环状β-1，2-葡聚糖，这对于将它们靶向到宿主细胞内内质网中的复制小生境是重要的。本文将重点关注LPS和环状β-1，2-葡聚糖在布鲁氏菌-哺乳动物感染中的作用，并讨论在这些细胞包膜结构的生物合成途径中使用突变体进行疫苗开发。
Brucella species are the causative agents of one of the most prevalent zoonotic diseases: brucellosis. Infections by Brucella species cause major economic losses in agriculture, leading to abortions in infected animals and resulting in a severe, although rarely lethal, debilitating disease in humans. Brucella species persist as intracellular pathogens that manage to effectively evade recognition by the host's immune system. Sugar-modified components in the Brucella cell envelope play an important role in their host interaction. Brucella lipopolysaccharide (LPS), unlike Escherichia coli LPS, does not trigger the host's innate immune system. Brucella produces cyclic β-1,2-glucans, which are important for targeting them to their replicative niche in the endoplasmic reticulum within the host cell. This paper will focus on the role of LPS and cyclic β-1,2-glucans in Brucella-mammalian infections and discuss the use of mutants, within the biosynthesis pathway of these cell envelope structures, in vaccine development.