Effect of mucosal healing (Mayo 0) on clinical relapse in patients with ulcerative colitis in clinical remission
Effect of mucosal healing (Mayo 0) on clinical relapse in patients with ulcerative colitis in clinical remission
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DOI：
10.3109/00365521.2016.1150503
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发表时间：
2016-01-01
影响因子：
1.9
通讯作者：
Kim, Won Ho
中科院分区：
文献类型：
--
作者：
Kim, Jae Hyun;Cheon, Jae Hee;Kim, Won Ho
目的：本研究的目的是确定粘膜愈合（MH）对临床缓解的溃疡性结肠炎（UC）患者临床复发的影响，特别参考Mayo内镜亚评分0。方法：回顾性分析2005年11月至2013年12月期间215例UC患者在临床缓解时接受结肠镜检查的医疗记录。内镜下MH定义为Mayo内镜评分0分（Mayo 0）。根据Mayo内镜评分将患者分为两组进行分析。结果：两组（MH与非MH）的基线特征，包括诊断年龄、性别、初始临床和结肠镜检查结果，没有显著差异。中位随访时间为80（12-118）个月。预测临床缓解持续时间较长的因素是诊断时年龄为30岁(30岁vs。
Objective: The aim of this study was to identify the effect of mucosal healing (MH) on clinical relapse in patients with ulcerative colitis (UC) who are in clinical remission, with special reference to Mayo endoscopic subscore 0.Methods: Between November 2005 and December 2013, medical records from a total of 215 patients with UC who underwent colonoscopic examination at the time of clinical remission were retrospectively reviewed. Endoscopic MH was defined as a 0 point' of Mayo endoscopic subscore (Mayo 0). Patients were categorized into two groups according to Mayo endoscopic subscore and then analyzed.Results: The baseline characteristics of both groups (MH vs. no-MH), including age at diagnosis, gender, and initial clinical and colonoscopic findings, were not significantly different. The median follow-up duration was 80 (12-118) months. Factors predictive of longer clinical remission duration were age 30years at diagnosis (30 years vs.